Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
Launched by UNIVERSITY OF NEW MEXICO · Mar 1, 2011
Trial Information
Current as of June 23, 2025
Completed
Keywords
ClinConnect Summary
The Intrauterine Device (IUD) is an excellent contraceptive option because of its ease of use, long term duration (5-10 years), low side-effect profile, and the immediate return to fertility after IUD removal. Despite advantages associated with the IUD, the smaller cervical diameter of nulliparous patients may lead to a more difficult and uncomfortable insertion. Some providers have started pre-medicating nulliparous patients with misoprostol prior to IUD insertion because of the drug's known effect as a cervical ripening agent. Limited evidence is available addressing the effect of misopro...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 14 years old or older
- • Negative pregnancy test
- • No prior pregnancies lasting beyond 19 6/7 weeks
- • Minimum 2 weeks after spontaneous or medical abortion
- • Minimum 4 weeks post 2nd trimester or surgical abortion
- • No previous IUD insertions
- • No PID in last 3 months
- • No current cervicitis
- • Willing to follow-up in 1-2 months for an IUD string check
- Exclusion Criteria:
- • Active cervical infection
- • Current pregnancy
- • Prior pregnancy beyond 19 6/7 weeks gestation
- • Known uterine anomaly
- • Fibroid uterus distorting uterine cavity
- • Copper allergy/Wilson's Disease (for Paragard)
- • Undiagnosed abnormal uterine bleeding
- • Cervical or uterine cancer
About University Of New Mexico
The University of New Mexico (UNM) is a leading academic institution dedicated to advancing healthcare through innovative research and clinical trials. With a robust commitment to improving patient outcomes, UNM leverages its interdisciplinary expertise and state-of-the-art facilities to conduct cutting-edge clinical research across various fields. The university fosters collaboration among researchers, clinicians, and community partners, ensuring that its trials are not only scientifically rigorous but also responsive to the needs of diverse populations. UNM is dedicated to translating research findings into practical applications, ultimately contributing to the enhancement of medical knowledge and the quality of care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Eve Espey, MD/MPH
Principal Investigator
University of New Mexico Department of Obstetrics and Gynecology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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