Safety and Efficacy of Long Limb Roux-en Y Reconstruction

Launched by GANGNAM SEVERANCE HOSPITAL · Jun 13, 2011

Keywords

ClinConnect Summary

Type II diabetes in the world is increasing rapidly, and it is known that patients with type II diabetes with morbid obesity that underwent bariatric surgery have resolution of impaired glucose metabolism.

In Asia, most type II diabetes are not morbidly obese and still, it is controversy whether metabolic surgery is effective or not in non-morbid obese patients. As life expectancy is increased, the number of patients with gastric cancer and T2DM is increased as well.

Recently, we studied the outcome of T2DM after gastrectomy and conventional reconstruction in non-obese gastric cancer pati...

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Eligibility criteria

• Inclusion Criteria:
• • Pathologically confirmed gastric cancer with potentially curable state
• • Non-obese (Body mass index: less than 30 kg/m2)
• • Have a history of Type 2 DM over 6 months (diagnosed by ADA criteria)
• • 1. HBA1c: more than 6.5 %, or Fasting glucose: more than 126 mg/dl (7.0mmol/L) or 2-h plasma glucose: more than 200mg/dl during an OGTT or classic symptoms of hyperglycemia or hyperglycemic crisis, a random plasma glucose: more than 200mg/dl
• • 2. Anti-GAD antibody (-), Anti-islet antibody (-)
• • C-peptide level: above 1ng/ml
• Exclusion Criteria:
• • Patient who receive non-curative operation
• • Patient who have less than one year life expectancy
• • Pregnant patient
• • Acute inflammation status patient
• • Chronic renal disease patient (Serum creatin level: more than 1.5mg/dl)
• • Chronic liver disease patient (Serum AST or ALT level: more than twice of upper limit of normal range)
• • Have a history of receiving medications such as dipeptidyl peptidase IV(DPP- IV) inhibitor or glucagon like peptide-I (GLP-I) analogue