A Study Of The Effects Of OC000459 In Subjects Known To Suffer From Grass Pollen Induced Allergic Rhinitis

Launched by OXAGEN LTD · Oct 6, 2011

Keywords

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Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Males aged 18 to 50 years with a history of symptoms of grass pollen related allergic rhinitis within the previous two years.
• • Subjects must be free from significant cardiac, pulmonary, gastrointestinal, hepatic, renal, haematological, neurological and psychiatric disease as determined by history, physical examination and screening investigations.
• • FEV1 within normal limits (≥90% of predicted).
• • Atopy defined by a positive cutaneous response to mixed grass pollen within the last 12 months or at screening.
• • Asymptomatic at screening
• • Non smokers for at least the past 12 months
• Exclusion Criteria:
• • Medical conditions likely to affect the outcome of the study.
• • Nasal conditions likely to affect the outcome of the study, i.e. nasal septal perforations, nasal polyps, sinus disease, chronic nasal obstruction, or other nasal diseases.
• • Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function
• • Immunotherapy treatment course including inhaled or local corticosteroids in the past 28 days.