Allopurinol in Acute Coronary Syndrome

Launched by STEPHEN MCSWIGGAN · Oct 20, 2011

Keywords

ClinConnect Summary

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Eligibility criteria

• Inclusion Criteria:
• • angiographically documented coronary artery disease,
• • a positive exercise tolerance test (ETT)
• • a history of symptoms of chronic, stable, effort-induced angina for ≥ 2 months.
• • All concomitant antianginal medication will be allowed and continued unchanged during the study.
• Exclusion Criteria:
• • the inability to do an ETT due to back or leg problems,
• • myocardial infarction or acute coronary syndrome ≤ 2 months,
• • coronary revascularization (percutaneous or CABG) ≤ 6 months,
• • Left Ventricular Ejection Fraction \<45%,
• • estimated GFR \<60 ml/min or creatinine \>180 mmol/ml,
• • significant valvular pathology,
• • already had gout or on allopurinol,
• • atrial arrhythmias or ECG abnormalities interfering with ST-segment interpretation,
• • previous ventricular arrhythmias on ETT,
• • severe hepatic disease
• • or on azathioprine, 6 mercaptopurine or warfarin.
• • Patients who have participated in any other clinical trial within the previous 30 days will be excluded.
• • Patients who are unable to give informed consent will also be excluded from this trial