Selenium Supplementation in Pregnancy

Launched by UNIVERSITY OF ROMA LA SAPIENZA · Nov 4, 2011

Keywords

ClinConnect Summary

Adverse outcomes, postpartum thyroid dysfunction and permanent hypothyroidism have been associated with isolated TPOab positivity in euthyroid pregnant women.

In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. Selenium-dependent enzymes also have several modifying effects on the immune system. Therefore, even mild selenium deficiency may contribute to the development and maintenance of autoimmune thyroid diseases.

Selenium substitution exerts anti-inflam...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • pregnant women with 10°± 2 weeks of gestation
• • women in whom embryo transfer is expected within 60 days
• • euthyroid women (0.4 μIU/ml \< TSH \< 2.5 μIU/ml), positive for TPOab and/or TgAb, not assuming LT4 replacement
• • euthyroid women (0.4 μIU/ml \< TSH \< 2.5 μIU/ml), positive for TPOab and/or TgAb under LT4 replacement (to maintain TSH within the control range).
• • women with TSH \> 2.5 μIU/ml positive for TPOab and/or TgAb, not assuming LT4 replacement (requiring the beginning of LT4 replacement)
• • women with TSH \> 2.5 μIU/ml positive for TPOab and/or TgAb, under LT4 replacement (requiring an adjustment of LT4 replacement)
• Exclusion Criteria:
• • use of dietary supplements containing selenium in the previous 4 months;
• • use of antidepressive/psychotic drugs, amiodarone, propanolol, lithium, cytokines;
• • history of hyperthyroidism positive anti-thyrotropin ab;
• • previous partial or total thyroidectomy;
• • known fetal anomaly;
• • known infections (PID, HIV, HCV) and mola hydatidoses;
• • chronic renal failure;
• • uncontrolled hypertension;
• • uterine malformation;
• • history of medical and metabolic complication such as heart disease or diabetes;
• • previous embryo transfer failed within last 3 months;
• • miscarriage within last 3 months;
• • gestational diabetes in previous pregnancies.