A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)

Launched by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST · Nov 30, 2011

Keywords

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of OHS
• • Age \>18
• • BMI \> 30 kg/m2
• • Chronic hypercapnia , daytime PaCO2 \>6kPa
• • FEV1/FVC ≥70%
• • Evidence of sleep disordered breathing on overnight studies
• • Tolerated NIV \> 4hrs on 1st night during initiation of NIV
• Exclusion Criteria:
• • Hypercapnic respiratory failure secondary to an identifiable cause other than OHS.
• • Age \<18
• • Respiratory acidosis (pH \<7.35)
• • Wheelchair/bedbound patients
• • Cognitive impairment which would prevent the subject from complying with trial protocol
• • Unstable coronary artery syndrome
• • Patients postintubation or decannulation following treatment requiring acute hypercapnic respiratory failure
• • Patients undergoing renal replacement therapy
• • Critical peripheral vascular disease
• • Disabling locomotor disability preventing participation in exercises involved in the rehabilitation programme
• • Pregnancy
• • Bariatric surgery planned within 3 months