The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on Proteinuria
Launched by MEDICAL UNIVERSITY OF GDANSK · Feb 28, 2012
Trial Information
Current as of June 17, 2025
Completed
Keywords
ClinConnect Summary
Pharmacological blockade of the renin-angiotensin-aldosterone system (RAAS) is the main target of therapy to reduces both proteinuria and the rate of decline of the glomerular filtration rate in non-diabetic chronic renal diseases. Despite recent progress, however, there is still no optimal therapy that can stop the progression of these nephropathies. Therefore, it is necessary to optimize such treatment for further improving renal outcome.
The aim of the present study was to compare the effects of three different types of RAAS blockade: (1) mineralocorticoid receptor blocker (MRB) + angio...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age 18-65 years
- • chronic non-diabetic proteinuric nephropathy
- • chronic kidney disease stage 1-3
- • stable proteinuria above 500 mg/24 hours
- • blood pressure above 125/75 mmHg and below 150/95 mmHg
- • no steroids or other immunosuppressive treatment for a minimum of six months before the study
- Exclusion Criteria:
- • unstable coronary heart disease
- • decompensated congestive heart failure in the previous 6 months
- • episode of malignant hypertension or stroke in the history
- • diabetes
- • creatinine clearance below 30 ml/min
- • pregnancy
About Medical University Of Gdansk
The Medical University of Gdańsk is a leading institution in healthcare education and research located in Gdańsk, Poland. Renowned for its commitment to advancing medical knowledge and improving patient outcomes, the university actively engages in innovative clinical trials across various medical disciplines. With a focus on multidisciplinary collaboration and state-of-the-art facilities, the Medical University of Gdańsk fosters an environment conducive to groundbreaking research and the development of novel therapeutic interventions. Its dedicated team of researchers, clinicians, and academic professionals is dedicated to enhancing healthcare through rigorous scientific inquiry and community engagement.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Bolesław Rutkowski, Professor
Principal Investigator
Departmen of Nephrology, Transplantation adn Internal Medicine, Medical University of Gdańsk, Poland
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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