The Effect of a Prebiotic, Probiotic and Synbiotic on the Gut Microbiota and Immune Response of Older Volunteers (GOS)
Launched by UNIVERSITY OF READING · Apr 24, 2012
Trial Information
Current as of September 25, 2025
Completed
Keywords
ClinConnect Summary
The primary objective of this study is to determine the effect of GOS (administered at 8g/day), B. lactis BI07 (administered at 109 CFU/day) and the synbiotic (8g/day of GOS and 109 CFU/day of B. lactis BI07) on the human gut microbiota.
A double-blind, placebo-controlled, randomized crossover study will be conducted in 40 healthy older (≥60 years of age) volunteers. The placebo will consist of maltodextrin (a food grade ingredient, administered at 8g/day).
Changes in the gut microbiota will be determined by measuring bacterial population levels in human faeces using 16S rRNA targeted oli...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • a signed consent form,
- • age \>60 years
- • good general health
- • not in the residential care.
- Exclusion Criteria:
- • evidence of physical or mental disease
- • planned major surgery
- • use of antibiotics within the previous six months
About University Of Reading
The University of Reading is a prestigious research institution in the United Kingdom, renowned for its commitment to advancing knowledge across various disciplines, including health sciences. As a clinical trial sponsor, the university leverages its cutting-edge research facilities and interdisciplinary expertise to conduct innovative studies aimed at improving healthcare outcomes. With a strong emphasis on ethical research practices and collaboration with industry partners, the University of Reading strives to contribute valuable insights to the field of medicine, fostering the development of new treatments and interventions that address pressing health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Reading, Berkshire, United Kingdom
Patients applied
Trial Officials
Robert A Rastall
Principal Investigator
University of Reading
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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