A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study)

Launched by CHINESE UNIVERSITY OF HONG KONG · May 4, 2012

Keywords

ClinConnect Summary

The Sibling AN Study is a clinical trial looking into the risk of colorectal neoplasms, which are abnormal growths in the colon, in siblings of patients who have been diagnosed with advanced adenomas. Advanced adenomas are larger growths that have certain features indicating a higher risk of developing cancer. The study aims to find out how common these neoplasms are in siblings compared to a similar group of individuals who do not have a family history of such conditions. Researchers will also look at the genetic changes in the growths of the siblings to understand the underlying risks better.

To be eligible for this study, participants must be siblings, aged between 40 and 70, of individuals who have been screened and found to have advanced adenomas. There is also a control group of siblings whose colonoscopy results were normal. Participants should not have a family history of specific hereditary cancer syndromes or other serious health issues that could complicate a colonoscopy procedure. If you join the study, you can expect to undergo tests that could help improve our understanding of colorectal health in families at risk. This research is important because it may lead to better screening and prevention strategies for colorectal cancer in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (case) Siblings (age \> 40 and \< 70) of individuals diagnosed with advanced neoplasm on screening colonoscopy. Advanced neoplasm is defined as adenomas ≥ 10mm size, \>25% villous features, severe dysplasia or carcinoma-in-situ
• • (control) Siblings of patients with negative findings on colonoscopy identified during the same study period, who are of the same age group as the studied cohort.
• Exclusion Criteria:
• • A family history compatible with that of Hereditary Non-polyposis Colon Cancer (HNPCC) based on the Amsterdam criteria \[Table 3\].
• • Known Familial Adenomatous Polyposis (FAP) syndrome
• • Patients and siblings with known inflammatory bowel disease
• • Siblings that have undergone colonoscopy examinations in the past
• • Severe cardio-pulmonary or other medical co-morbidities that preclude safe colonoscopic examination