Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque

Launched by UNIVERSITY OF LAUSANNE HOSPITALS · May 28, 2012

Keywords

ClinConnect Summary

This clinical trial is investigating a new imaging technique called 68Ga-NODAGA-RGD PET/CT to see if it can better identify inflammatory plaques in the carotid arteries compared to other imaging methods like 18F-FDG PET/CT, MRI, and ultrasound. These plaques can lead to serious conditions such as strokes, and the study hopes to find out which imaging method provides the best information for patients who may need a specific surgery known as carotid endarterectomy, which helps to improve blood flow by removing these plaques.

To participate in the trial, individuals need to be between the ages of 65 and 85, in generally good health (with a score of 80% or higher on a health assessment scale), and have a recommendation for the endarterectomy surgery. Participants will undergo several imaging tests and will be monitored closely. It's important to know that not everyone can participate; those with certain health conditions, such as severe kidney issues or who are pregnant, will not be eligible. If you or a family member are interested, be sure to discuss it with your healthcare provider for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \<= 85 years
• • Karnofsky \>= 80%
• • patient with indication ofr carotid endarterectomy
• • signed consent form
• Exclusion Criteria:
• • indication for surgery other than endarterectomy \<14 days
• • contraindication to surgery
• • contraindication to MRI
• • contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR\<30ml/min/1.73m2)
• • pregnancy, breastfeeding
• • lack of discernment