An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Aug 15, 2012

Keywords

ClinConnect Summary

This clinical trial is exploring how brain tumors use glucose, a type of sugar, to grow and behave. Researchers want to understand the metabolism of brain tumors in patients who are scheduled for surgery to remove a tumor. By giving patients a special type of glucose that isn’t radioactive, they will analyze tumor samples and perform advanced imaging tests to see how the tumor is functioning. This study aims to identify active tumor cells that may be spreading and to create a detailed profile of the tumor's characteristics.

To participate, patients need to be at least 18 years old and have a brain tumor that is confirmed by imaging. They should be able to give consent for themselves or have a guardian who can. Patients will undergo imaging tests and provide tumor samples during their surgery. Throughout the study, researchers will monitor the patients' treatment progress and health to see how the tumor responds. It’s important to note that some patients may not be eligible due to certain health conditions or if they have devices that may interfere with MRI scans.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female, any age and any racial or ethnic group
• • Spanish-speaking patients will be eligible
• • Pre-operative brain MR imaging suggestive of a brain tumor or pre-operative imaging showing a tumor or biopsy of a tumor mass prior to planned resection of the mass
• • Patient able and willing to provide informed consent or Legal parent or guardian willing and able to provide informed consent for patient under age 18.
• • Karnofsky Performance status \> 70%
• • Negative serum pregnancy test or child bearing potential terminated by surgery, radiation, menopause or current use of two approved methods of birth control
• Exclusion Criteria:
• • Patient or legal parent/guardian unable to provide informed consent
• • Karnofsky Performance status \< 70%
• • Patients who are claustrophobic or have other contraindications to MRI, such as impanted pacemaker device vascular clips, surgical clips, prosthetic valves, pacemakers, otologic implants
• • NYHA class III and IV congestive heart failure
• • Psychiatric or addictive disorders that preclude obtaining informed consent
• • Unstable angina
• • Pregnant or lactating women
• • Women of childbearing potential who refuse a pregnancy test (performed during screening)