ERA Test in Patients With Recurrent Implantation Failure

Launched by IGENOMIX · Aug 16, 2012

Keywords

ClinConnect Summary

Intervention(s): Endometrial sampling, either at LH+7 in a natural cycle or after 5 days of progesterone in a hormonal replacement cycle (HRT) and personalized embryo transfer (pET) on the designated day guided by the ERA prediction.

Repeated implantation failure (RIF) is an unsolved not well characterized major cause of infertility in otherwise healthy women. Although various definitions of RIF exist, the clinical community agrees that after failure of three IVF cycles, in which one to two morphologically high-grade embryos have been transferred, special protocols must be enforced, althou...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women ≤38 years old
• • Normal ovarian reserve
• • FSH \<8mIU/mL
• • Cycle with ≥6 MII oocytes/oocyte retrieval
• • ≥3 implantation failures in previous IVF/ICSI cycles with transfer of atleast two good quality embryos in each cycle Inclusion Criteria for ovum donation recipients
• • ≥3 implantation failures with transfer of atleast two good quality embryos in each cycle
• • Endometrial thickness ≥ 6 mm
• • Trilaminar pattern after proper progesterone priming
• Exclusion Criteria:
• • Existance of hydrosalpinx
• • Atrophic endometrium \< 6 mm
• • Previous ectopic or uterine miscarriages
• • Presence of myomas or polyps
• • Previous embryo transfer with high difficulty and/or bleeding