Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES · Sep 12, 2012

Keywords

ClinConnect Summary

The secondary objectives of this study are:

* To compare the efficacy (non-inferiority) of intravenous paracetamol and ketoprofen at 90 minutes (vns for pain).
* To compare both arms in terms of other administered drugs (for pain).
* To observe and compare side effects between the two arms: cutaneous manifestation, edema, bronchospasm, nausea, vomiting, headache, palpitation, chest pain, dizziness, disturbance of consciousness, dyspnea, acute retention of urine.
* To determine predictors for the use of intravenous morphine when treating renal colic.
* To compare hospitalization rates betwe...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The patient must have given his/her informed and signed consent
• • The patient must be insured or beneficiary of a health insurance plan
• • The patient is available for a telephone interview at week 1
• • Patient consulting at the Nîmes University Hospital emergency ward with suspicion of renal colic
• Exclusion Criteria:
• • The patient is participating in another study
• • The patient is in an exclusion period determined by a previous study
• • The patient is under judicial protection, under tutorship or curatorship
• • The patient refuses to sign the consent
• • It is impossible to correctly inform the patient
• • The patient is pregnant, parturient, or breastfeeding
• • The patient has a contraindication for a treatment used in this study
• • The patient has an allergy to ketoprofen or paracetamol, a history of gastric or intestinal ulcers, bleeding disorders, history of asthma triggered by taking ketoprofen or substances with similar activity such as other NSAIDs or aspirin
• • The patient has a fever or is hemodynamically unstable, oligoanuria
• • The patient presents with an initial verbal numeric pain score of 10/10.
• • The patient has a history of aneurysm or aortic dissection, history of renal transplantation, history of renal or hepatic insufficiency
• • The patient took paracetamol or ketoprofen 4 hours before emergency treatment.