Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Sep 20, 2012

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age ≥ 18
• • Severe sepsis or septic shock
• • Central venous catheter (for blood drawing)
• Exclusion Criteria:
• • Serum calcium ≥ 10.0 mg/dl or phosphate ≥ 6.0 mg/dl, assessed within previous 48 hours
• • Current or recent therapy (within previous 7 days) with nutritional vitamin D at doses \>1,000 I.U. per day or activated vitamin D at any dose
• • History of solid organ or bone marrow transplant, primary parathyroid disease, metabolic bone disease, or sarcoidosis
• • Expected to die or leave the ICU within 48 hours
• • History of hypersensitivity or any allergic reaction to calcitriol
• • End stage renal disease
• • Acute Kidney Injury receiving intermittent renal replacement therapy
• • Enrolled in a competing study
• • Pregnancy