COsegregation of VARiants in Panel of Genes

Launched by INSTITUT CURIE · Sep 20, 2012

Keywords

ClinConnect Summary

The COsegregation of VARiants in Panel of Genes (COVAR) trial is studying how to better understand specific gene changes that may increase the risk of certain cancers. These changes, known as variants, can sometimes be unclear in terms of their significance, which is why this research aims to classify them accurately. The information gathered from this study will help doctors give better advice to patients and their families about managing their cancer risk, and in some cases, it could even lead to the recommendation of preventive surgeries.

To participate in this trial, you must be at least 18 years old and either have a specific gene variant linked to cancer (known as an "index case") or be a family member of someone who does. If you're selected, you'll be asked to provide written consent to take part in the study. The trial is currently looking for participants, and it's open to all genders. If you join, you can expect to help advance our understanding of genetic risks for cancer, which could ultimately benefit many families facing similar challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Index cases:
• • A person carrying a gene variant class 3 or 4, present and selected in the families of national database of genetic group and cancer (GGC Unicancer) which identifies the variations of all genes from the panel of genes of all French laboratories.
• • Age ≥ 18 years.
• • Signed written inform consent "index case"
• Related parties:
• • Any relative of an index case with cancer
• • Any relative without cancer related to an index case, retained by investigators, based on family structure and degree of related compared to the index case
• • Age ≥ 18 years
• • Information and signature of the informed consent "selected relatives"
• Exclusion Criteria:
• • Minors
• • Persons deprived of liberty or under guardianship (including curators).
• • Absence of signed written inform consent