Endomicroscopy, IBS and Food Intolerance

Launched by UNIVERSITY HOSPITAL SCHLESWIG-HOLSTEIN · Sep 20, 2012

Keywords

ClinConnect Summary

The primary endpoint is the visible marked increase of lymphocytes and mononuclear cells in the lamina propria of the duodenum, representing an acute reaction to one of the allergens sprayed to its surface through the endoscope channel.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \> 18 years
• • ongoing abdominal symptoms such as bloating and abdominal pain
• • negative routine testing for food intolerance (or known lactose/fructose intolerance)
• • written informed consent
• Exclusion Criteria:
• • no consent
• • known reason for the abdominal pain and bloating other than lactose/fructose intolerance
• • M. Whipple
• • known infectious gastrointestinal disease
• • stricture in the upper gastrointestinal tract
• • age \>18years
• • impaired renal function (Creatinine \>1.2 mg/dL)
• • pregnancy or breast feeding
• • inability to obtain informed consent
• • active GI Bleeding
• • known allergy to Methylene blue or Fluorescein
• • participation in other clinical trials within the last 4 weeks