L-ornithine L-aspartate in Overt Hepatic Encephalopathy

Launched by DAYANAND MEDICAL COLLEGE AND HOSPITAL · Nov 6, 2012

Keywords

ClinConnect Summary

A. Introduction and Review of literature

Hepatic encephalopathy (HE) is broadly defined as an alteration in mental status and cognitive function occurring in presence of liver failure. The clinical picture of HE arises as a complication of chronic and, more rarely, acute liver disease. HE occurs in up to 70% of patients with cirrhosis at some time during the course of their disease (1,2). It is characterized by personality changes, intellectual impairment and a depressed level of consciousness. HE may be clinical unapparent (minimal HE) detected by abnormal neuropsychometric or neurophysio...

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Eligibility criteria

• Inclusion Criteria:
• • Hepatic cirrhosis based on clinical, biochemical, radiological and/or histological data
• • Patients with overt acute grade 2, 3 and 4 HE, according to the West Haven criteria, with or without precipitating factors.
• • Age of patient 18-70 years
• Exclusion Criteria:
• • Patients who are terminally ill
• • Acute on chronic liver failure
• • Hepatocellular carcinoma
• • Wilson's disease as the etiological factor of liver disease
• • Advanced cardiac or pulmonary disease
• • Presence of underlying chronic renal failure
• • Neuro-degenerative disease or major psychiatric illness
• • Patients on sedatives or antidepressants
• • Pregnancy or breastfeeding