Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment

Launched by RADBOUD UNIVERSITY MEDICAL CENTER · Nov 13, 2012

Keywords

ClinConnect Summary

Rationale: Primary aldosteronism (PA) is the most frequent form of secondary hypertension. It is caused by autonomous secretion of aldosterone, encompassing a group of disorders which is for more than 99% predominated by unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH). Diagnosis of PA is relevant for two reasons: 1) independent of the level of blood pressure, hypertension due to autonomous aldosterone secretion causes more cardiovascular damage than essential hypertension; 2) PA requires specific treatment: adrenalectomy in case of APA and mineralocort...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Part 1:
• • 1. Newly diagnosed hypertensive patients (according to the NHG-guideline 'Cardiovascular risk management');
• • 2. 18 years or older;
• • 3. No use of antihypertensive medication.
• Part 2:
• • 1. Patients with increased aldosterone/renin ratio;
• • 2. Positive sodium loading test;
• • 3. Written informed consent.
• Part 2 + 3:
• • 1. Patients with normal aldosterone/renin ratio;
• • 2. Normal ARR;
• • 3. Written informed consent.
• Part 3:
• • 1. Patients with increased aldosterone/renin ratio;
• • 2. Positive sodium loading test;
• • 3. Normokalemic;
• • 4. Written informed consent.
• Exclusion Criteria:
• • 1. Use of antihypertensive medication;
• • 2. Heart failure class II, III or IV (according to the New York Heart Association);
• • 3. Pregnancy or breastfeeding.