Motile Sperm Organelle Morphology Examination (MSOME) Influence on Intracytoplasmic Sperm Injection (ICSI) Outcomes in Infertile Couples
Launched by SAPIENTIAE INSTITUTE · Nov 21, 2012
Trial Information
Current as of July 23, 2025
Completed
Keywords
ClinConnect Summary
Sperm morphology has been described as one of the major determinants of male in vitro fertility. However, the standard morphology evaluation on random stained cells from the ejaculate is of limited value during ICSI. Current research is directed towards the dysmorphisms of the sperm head.A new technique based on the motile sperm organelle morphology examination (MSOME) at a magnification of at least ×6000 has been developed. The MSOME assesses the nucleus, for both shape and chromatin content, which is the most important sperm organelle in influencing ICSI outcomes. The goals for this study...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Couples undergoing ICSI as result of male factor or tubal factor or unexplained infertility
- • Women with regular menstrual cycles of 25-35 days
- • Women with normal basal follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels
- • Women with body mass index (BMI) less than 30 kg/m2
- • Women with both ovaries and intact uterus
- Exclusion Criteria:
- • Women with polycystic ovaries syndrome
- • Women with endometriosis
- • Women with gynaecological/medical disorders
- • Couples with any sexually transmitted disease
- • Women who had received any hormone therapy for less than 60 days preceding the study
About Sapientiae Institute
The Sapientiae Institute is a leading clinical trial sponsor dedicated to advancing medical research and improving patient outcomes through innovative therapeutic solutions. With a strong emphasis on ethical standards and scientific rigor, the Institute collaborates with academic institutions, healthcare providers, and industry partners to design and conduct clinical trials across various therapeutic areas. Committed to transparency and integrity, the Sapientiae Institute aims to facilitate the efficient development of safe and effective treatments, contributing to the overall enhancement of global health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
São Paulo, , Brazil
São Paulo, , Brazil
Patients applied
Trial Officials
Edson Borges Jr., MD., PhD
Principal Investigator
Sapientiae Institute
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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