Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN)

Launched by YALING HAN · Nov 27, 2012

Keywords

ClinConnect Summary

Through a number of large-scale clinical trials , Meta analysis, and clinical treatment guidelines confirm that clopidogrel and aspirin dual antiplatelet treatment strategies for acute coronary syndrome (ACS) undergoing percutaneous coronary interventions(PCI) of stent implantation surgery patients have a vital role . It can effectively suppress acute 、subacute stent thrombosis formation , reduce readmissions ratio , thus greatly improving the quality of life of patients . A large number of clinical practice reports, although the treatment strategies to reduce the incidence of adverse cardi...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. ACS (including unstable angina pectoris, non-ST-segment elevation myocardial infarction and ST-elevation myocardial infarction) ;
• • 2. The age between18 and 75 ;
• • 3. Informed consent.
• Exclusion Criteria:
• • 1. Receiving GP IIb / IIIa receptor antagonist treatment;
• • 2. Had received prior to enrollment 7d cilostazol;
• • 3. Dual antiplatelet therapy contraindications;
• • 4. NYHA grade III \~ IV;
• • 5. Presence of multivessel severe coronary lesions , need elective coronary revascularization;
• • 6. The need for long-term use of warfarin after valve surgery or persistent atrial fibrillation;
• • 7. Severe liver or kidney dysfunction;
• • 8. Has not been cured of peptic ulcer or presence of bleeding tendency;
• • 9. Who complicate the known bleeding tendency and blood system diseases;
• • 10. Have a history of intracranial hemorrhage within 6 monhs;
• • 11. Planned surgery recently;
• • 12. Pregnancy;
• • 13. Other serious illness, life expectancy less than 6 months;
• • 14. Nearly 1 year underwent PCI , regular take aspirin 、clopidogrel since;