TEP With 68-DOTANOC in Gastroenteropancreatic Neuroendocrine Tumors

Launched by NANTES UNIVERSITY HOSPITAL · Dec 10, 2012

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age over 18 years
• • effective contraception or exclusion of pregnancy dosage of beta-HCG in women of childbearing age
• • Fortuitous discovery of suggestive tumors of TE-GEP with well documented conventional imaging (multiphase CT; MRI, US endoscopy) associated or not associated with clinical or biological signs of TE-GEP tumors (increase in tumor markers) OR
• • Histologically proven GEP-TE (WHO classification 2010 (26) well differentiated in the initial staging OR
• • Suspicion of recurrence or progression of well differentiated TE-GEP tumors on conventional imaging or laboratory tests (increase in tumor markers) OR
• • Clinical or biological syndrome strongly suggestive of digestive endocrine disease without identification of lesions with conventional imaging
• • Informed consent and patient's written
• • Affiliation to an insurance
• Exclusion Criteria:
• • Multiple endocrine neoplasia
• • TE GEP tumor not differentiated
• • Pregnancy and lactation
• • Persons protected by law
• • Restlessness, inability to lie still hold at least 1 hour; Claustrophobia
• • Poor compliance predictable or inability to undergo medical test for geographical, social or psychological
• • Treatment with radiotherapy, chemotherapy or other antitumor treatment within 6 weeks of previous morphological and scintigraphic examinations. In case of treatment with somatostatin analogues delayed, scans will be performed 4 weeks after the last injection. However, a shorter period may be observed to avoid to do again the initial assessment exams.
• • malignancy except basal cell cancers and cancer in situ of the cervix
• • Contraindication of injection of a contrast agent necessary for the production of multiphase scanner.
• • Patients who had a CT scan without injection of contrast material can not participate in the study