Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis
Launched by BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY, DHAKA, BANGLADESH · Dec 11, 2012
Trial Information
Current as of July 08, 2025
Completed
Keywords
ClinConnect Summary
Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment.
Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsen...
Gender
ALL
Eligibility criteria
- Inclusion Criteria (Patients):
- • history of taking arsenic contaminated water (\>50 ppb) for more than 6 months
- • patients having mild to moderate arsenical keratosis present on palm of the hand
- • patients those voluntarily agree to participate
- Inclusion Criteria (Arsenic exposed controls):
- • family member of the patient
- • drinking arsenic contaminated water from the same source as patient
- • those voluntarily agree to participate
- • no sign/symptom of palmer keratosis
- Inclusion Criteria (Healthy volunteers):
- • drinking arsenic safe water (\<50 ppb)
- • those voluntarily agree to participate
- Exclusion Criteria:
- • pregnancy
- • lactating mother
- • patient receiving treatment of arsenicosis
- • any other chronic disease like tuberculosis, diabetes mellitus, bronchial asthma
About Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka, Bangladesh, is a premier institution dedicated to advancing medical education, research, and healthcare services. As a leading clinical trial sponsor, BSMMU is committed to fostering innovative research initiatives that enhance patient care and contribute to the global medical community. The university boasts a multidisciplinary team of experts and state-of-the-art facilities, enabling the conduct of rigorous clinical trials across various therapeutic areas. With a focus on ethical standards and patient safety, BSMMU aims to facilitate the development of new treatments and improve health outcomes both locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Dhaka, , Bangladesh
Patients applied
Trial Officials
Mir Misbahuddin, MBBS, PhD
Principal Investigator
Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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