Validation of Hand Held Dynamometer for Assessment of Lower Limb Muscle Strength in Multiple Sclerosis

Launched by BROWN, THEODORE R., M.D., MPH · Dec 12, 2012

Keywords

ClinConnect Summary

Purpose of this study is to assess the intra-rater and inter-rater reliability of a hand-held dynamometer (HHD) in the assessment of lower limb strength in patients with Multiple Sclerosis.

Also to establish a standardized strength testing procedure for key lower limb muscle groups using a HHD fo research and clinical purposes in Multiple Sclerosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Stable patients with clinically definite Multiple Sclerosis
• • No Multiple Sclerosis exacerbation 30 days prior to screening
• • No change in disease modifying therapy for 30 day prior to screening
• Exclusion Criteria:
• • Inflammatory myopathy
• • Endocarditis, pericarditis o rother unstable heart disease
• • Cardiac surgery or myocardial infarction in the last 3 months
• • Decompensated congestive heart failure
• • Severe aortic stenosis
• • Severe pulmonary hypertension
• • Pulmonary embolus or infarction in the last 6 months
• • Uncontrolled hypertension by history or by screening or baseline diastolic blood pressure \>170 or systolic blood pressure \>105
• • Concomitant neurodegenerative neurological disease such as Amyotrophic Lateral Sclerosis (ALS) Parkinsons or hemiplegic stroke
• • females who are pregnant
• • Cognitive deficits that would interfere with the subjects's ability to give informed consent or preform study testing
• • Painful orthopedic condition affecting the lower limbs
• • Any other serious and/or unstable medical condition