NAC Supplementation and Skeletal Muscle Performance
Launched by DEMOCRITUS UNIVERSITY OF THRACE · Jan 25, 2013
Trial Information
Current as of June 18, 2025
Completed
Keywords
ClinConnect Summary
The major thiol-disulfide couple of reduced (GSH) and oxidized glutathione (GSSG) is a key-regulator of major transcriptional pathways regulating aseptic inflammation and recovery of skeletal muscle following aseptic injury. Antioxidant supplementation may hamper exercise-induced cellular adaptations.
Our objective was to examine how thiol-based antioxidant supplementation affects skeletal muscle's performance and redox-sensitive signalling during the inflammatory and repair phases associated with exercise-induced micro-trauma.In a double-blind, counterbalanced design, 12 men received plac...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • a) recreationally trained as evidenced by their maximal oxygen consumption levels (VO2max \>45 ml/kg/min), b) were engaged in systematic exercise at least three times/week for ≥12 months), c) non-smokers, d) abstained from any vigorous physical activity during the study, e)abstained from consumption of caffeine, alcohol, performance-enhancing or antioxidant supplements, and medications during the study.
- Exclusion Criteria:
- • a) a known NAC intolerance or allergy, b) a recent febrile illness, c) history of muscle lesion, d) lower limb trauma
About Democritus University Of Thrace
Democritus University of Thrace is a leading academic institution in Greece, renowned for its commitment to advancing health sciences through innovative research and clinical trials. The university's research initiatives are driven by a multidisciplinary approach, fostering collaboration among experts in medicine, pharmacology, and biotechnology. With a focus on improving patient outcomes and contributing to the global body of medical knowledge, Democritus University of Thrace actively sponsors clinical trials that address critical health challenges, ensuring adherence to the highest ethical and scientific standards. Through its dedication to education and research, the university plays a pivotal role in shaping the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Komotini, Thrace, Greece
Patients applied
Trial Officials
Ioannis F Fatouros, Ph.D.
Principal Investigator
Democritus University of Thrace, Greece
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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