Effect of Sacral Nerve Stimulation on Enteric Nervous System
Launched by UNIVERSITY HOSPITAL, ROUEN · Feb 6, 2013
Trial Information
Current as of August 02, 2025
Completed
Keywords
ClinConnect Summary
Sacral nerve stimulation (SNS) is a new therapeutic option to treat fecal incontinence. Its efficacy yields 80% approximately, but its mecanims of action remains poorly understood. In particular, SNS does not restore anal squeezing contraction nor it increase anal tone. Recently, using a porcine model, it was shown that SNS changed colonic permeability, suggesting that SNS may activate the enteric nervous system (ENS).
The investigators hypothtized therefore that SNS could act on enteric nervous system (ENS).
To verify this hypothesis, the investigators will collect biopsy samples from pa...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Fecal incotinence
- • refractory to medial treatment
- • Eligible to a treatment with sacral nerve stimulation
- Exclusion Criteria:
- • age \< 18 yo
- • age \< 75 yo
- • anal defect \> 120°
- • bilateral interruption of the bulbo-cavernous reflex
- • patient not able to speack and understand the French Language
- • patient not affilated to the French healthcare system
- • pregnancy
About University Hospital, Rouen
The University Hospital of Rouen is a leading medical institution dedicated to advancing healthcare through innovative research and clinical trials. As a prominent academic hospital, it integrates cutting-edge medical education with patient care, fostering an environment where clinical research is paramount. With a multidisciplinary team of expert clinicians and researchers, the hospital focuses on a wide range of therapeutic areas, aiming to improve patient outcomes and contribute to the global medical community. The University Hospital of Rouen is committed to ethical standards and rigorous scientific methodologies, ensuring the highest quality of care and research integrity in all its clinical trials.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rouen, , France
Nantes, Pays De Loire, France
Rouen, Normandy, France
Patients applied
Trial Officials
Guillaume Gourcerol, MD, PhD
Principal Investigator
Rouen University Hospital, France
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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