Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Mar 8, 2013

Keywords

ClinConnect Summary

The Morphea in Adults and Children (MAC) study is a special research project aimed at better understanding morphea, a condition that causes patches of hard skin. This is the first registry in the country that includes both adults and children with morphea. The main goals of this study are to learn how morphea changes over time, how often it leads to other issues like arthritis, and whether it has ties to autoimmune diseases, which are conditions where the body’s immune system mistakenly attacks itself.

To participate in this study, individuals must have a confirmed diagnosis of morphea and be between 0 to 90 years old. Children must weigh more than 20 pounds to ensure safe blood draws. The study welcomes all genders and backgrounds, and it’s important that participants or their guardians can understand the information provided at a sixth-grade reading level. Participants can expect to share their medical information and may have some tests done to help researchers learn more about morphea. This is a great opportunity to contribute to important research that could benefit others with this condition in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient must have a clinical diagnosis of morphea confirmed by the primary investigator and by histopathological examination.
• • 2. Ages 0-90 years old
• • 3. Children must weigh more than 20 lbs. in order to satisfy Children's Medical Center policy for the maximum amount of blood drawn in a 24 hour period.
• • 4. Patient or legal guardian must be able to speak and read at a 6th grade reading level.
• • 5. Both male and female patients will be eligible
• • 6. All races and ethnic backgrounds will be included
• • 7. Relationships to proband: All patients with morphea will be included. A patient's family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigator's contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so.
• • 8. Ability to give informed consent: Patients must be able to give informed consent or they will give assent with parent or guardian consent as a minor to be a part of the morphea registry.
• Exclusion Criteria:
• • - Patients who have been coded as morphea (701.0), but do not have morphea/localized scleroderma (examples: steroid atrophy, acquired keratoderma, keloids, nephrogenic fibrosing dermopathy, systemic sclerosis, lichen sclerosis)