Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope

Launched by POLICLINICO CASILINO ASL RMB · Mar 15, 2013

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Eligibility criteria

• • Twenty consecutive patients affected by cardioinhibitory neurocardiogenic syncope will be enrolled in the study.
• Inclusion criteria:
• • age between 18 and 60 years
• • 3 syncopal episodes at least of likely CNS in the previous 2 years
• • marked cardioinhibitory response to HUT or documented asystolic pauses at internal loop recorder registration \[7\].
• • Cardioinhibition will be considered as elicitation of asystolic pause (sinus arrest or AV block) ≥ 3 seconds associated to syncope or ≥ 6 seconds and related presyncope.
• Exclusion criteria:
• • documented myocardial and/or valvular abnormalities on 2D echocardiogram (ejection fraction lower than 50%)
• • documented tachyarrhythmias as possible causes of symptoms
• • channelopathies (Brugada syndrome, LQT or SQT syndrome)
• • ventricular preexcitation
• • symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement
• • pregnancy in women
• • previous cardiac pacemaker implantation.