Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus
Launched by ODENSE UNIVERSITY HOSPITAL · Mar 28, 2013
Trial Information
Current as of May 21, 2025
Completed
Keywords
ClinConnect Summary
Study aim and hypothesis:
Aim:
To test whether there is a measurable correlation between plasmin/plasminogen, abnormally excreted in the kidneys, and the development of pre-eclampsia in pregnant women with Type 1 diabetes.
Hypothesis:
1. The amount of proteases ( plasmin/plasminogen ), excreted in urine, predicts development of preeclampsia in pregnant patients with type 1 diabetes.
If a correlation between excreted plasmin/plasminogen, in urine, in patients with type 1 diabetes and development of preeclampsia, are seen, proteases might be used as a marker for pre-eclampsia in this gro...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • singleton gravida,
- • over 18 years,
- • Pregestational type 1 diabetes. Gestation week 8-14.
- Exclusion Criteria:
- • 1. Possible comorbidity like systemic lupus erythematosus (SLE), hypertension and rheumatoid arthritis.
- • 2. Organic or systematic diseases with clinical relevance ( ex. Malignity)
- • However it has to be mentioned that quite some patients have thyroid diseases with no impact on the kidneys nor hypertension. It is therefore possible to include these patients.
- • Thyroid diseases are NOT a reason for exclusion.
About Odense University Hospital
Odense University Hospital is a leading academic medical center located in Denmark, dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital is committed to enhancing patient outcomes and fostering collaboration among multidisciplinary teams. With a focus on translating scientific discoveries into practical applications, Odense University Hospital leverages its state-of-the-art facilities and expertise to conduct rigorous trials across various medical fields, ensuring adherence to the highest ethical and regulatory standards. Through these efforts, the hospital aims to contribute significantly to the global body of medical knowledge and improve the quality of care for patients both locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Skejby, Aarhus N, Denmark
Patients applied
Trial Officials
Boye L. Jensen, Professor
Study Director
cardiovascular and renal research department, Odense University Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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