Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Launched by BRISTOL-MYERS SQUIBB · Apr 23, 2013
Trial Information
Current as of August 22, 2025
Recruiting
Keywords
ClinConnect Summary
The PREAMBLE study is looking at how effective different treatments for multiple myeloma (a type of blood cancer) are in real-life situations. This includes examining both newly diagnosed patients and those whose cancer has come back or didn’t respond to earlier treatments. The researchers want to understand how well these treatments work outside of a clinical trial setting, where patients are often closely monitored and selected for specific criteria.
To participate in this study, participants must be between the ages of 65 and 74 and can include both men and women. Eligible patients with relapsed or refractory multiple myeloma should have already tried at least one treatment before joining the study. For those newly diagnosed, they should be starting their first treatment. Participants will need to begin their treatment shortly after agreeing to join the study. It’s important to note that people currently involved in another clinical trial for multiple myeloma or those receiving treatment for different types of cancer aren’t eligible. Participants can expect regular check-ups and will help researchers gather important information about their treatment outcomes. For more details, you can visit www.BMSStudyConnect.com.
Gender
ALL
Eligibility criteria
- • For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com
- Inclusion Criteria:
- For RRMM participants who have received at least one prior line of therapy (LoT) for MM:
- • Have documented progression from a prior LoT
- * Participants who have initiated treatment with one of the following therapies within 90 days before consent for this study OR in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent:
- • IMiDs
- • PIs
- • Combination of IMiD + PI
- • Newer agents with novel MOAs alone or in combination (eg, mAbs, HDACIs, Akt inhibitors, SINE, or CAR T-cell therapies)
- For NDMM participants receiving frontline therapy:
- • Eligible to receive frontline therapy for MM (no prior MM treatment)
- * Participants who have initiated treatment for MM with one of the following therapies within 90 days before consent for this study OR in the case where treatment has not yet been initiated, documentation that the treatment strategy was determined before consent for this study must be provided, and treatment must be initiated within 30 days after consent:
- • IMiDs
- • PIs
- • Combination of IMiD + PI
- • Newer agents with novel MOAs alone or in combination (eg, mAbs, HDACIs, Akt inhibitors, SINE, or CAR T-cell therapies)
- Exclusion Criteria:
- • Participants who are currently participating in a clinical trial for MM
- • Participants who are currently receiving treatment for primary cancer other than MM
- • Participants who are not willing or able to provide informed consent
- • Participants who are incarcerated
- • Participants under compulsory detention for treatment of a physical (eg, infectious) or psychiatric illness
- • Other protocol-defined inclusion/exclusion criteria apply
About Bristol Myers Squibb
Bristol-Myers Squibb (BMS) is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With a robust portfolio of products across multiple therapeutic areas, including oncology, immunology, cardiovascular, and fibrotic diseases, BMS emphasizes cutting-edge research and a commitment to advancing medical science through clinical trials. The company is driven by a mission to provide transformative therapies, leveraging collaboration and scientific expertise to address unmet medical needs and improve patient outcomes worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Yakima, Washington, United States
Des Moines, Iowa, United States
Cleveland, Ohio, United States
Jackson, Mississippi, United States
Kansas City, Missouri, United States
Spokane, Washington, United States
Washington, District Of Columbia, United States
Seattle, Washington, United States
Dallas, Texas, United States
Knoxville, Tennessee, United States
Louisville, Kentucky, United States
Stony Brook, New York, United States
Dresden, , Germany
Roma, , Italy
Liverpool, , United Kingdom
Burbank, California, United States
Birmingham, Alabama, United States
Heidelberg, , Germany
Cary, North Carolina, United States
Nantes, , France
Rennes, , France
Milano, , Italy
Aschaffenburg, , Germany
Anaheim, California, United States
Woodbury, Minnesota, United States
Amarillo, Texas, United States
Vicenza, , Italy
Fountain Valley, California, United States
Limoges, , France
Gastonia, North Carolina, United States
Firenze, , Italy
Roma, , Italy
Canton, Ohio, United States
San Antonio, Texas, United States
London, Kentucky, United States
Terni, , Italy
Downey, California, United States
Lecce, , Italy
Torino, , Italy
Rostock, , Germany
Jacksonville, Florida, United States
Savannah, Georgia, United States
Shreveport, Louisiana, United States
Shreveport, Louisiana, United States
Hamm, , Germany
Does Not Exist, New Jersey, United States
Köln, , Germany
Pesaro, , Italy
San Giovanni Rotondo (Fg), , Italy
Birmingham, Alabama, United States
Brooksville, Florida, United States
Springfield, Missouri, United States
Memphis, Tennessee, United States
La Roche Sur Yon Cedex 9, , France
Oldenburg, , Germany
Truro, , United Kingdom
Cagliari, , Italy
Pescara, , Italy
Swansea, , United Kingdom
Muenchen, , Germany
Santa Rosa, California, United States
Muscle Shoals, Alabama, United States
Goodyear, Arizona, United States
Anaheim, California, United States
Corona, California, United States
Los Angeles, California, United States
Santa Rosa, California, United States
Brooksville, Florida, United States
Fort Lauderdale, Florida, United States
Jacksonville, Florida, United States
Valdosta, Georgia, United States
Valdosta, Georgia, United States
Skokie, Illinois, United States
Springfield, Illinois, United States
Urbana, Illinois, United States
Anderson, Indiana, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Sioux City, Iowa, United States
Sioux City, Iowa, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Lafayette, Louisiana, United States
Lafayette, Louisiana, United States
Minneapolis, Minnesota, United States
Southaven, Mississippi, United States
Kansas City, Missouri, United States
Missoula, Missouri, United States
Saint Joseph, Missouri, United States
Saint Louis, Missouri, United States
Saint Louis, Missouri, United States
Springfield, Missouri, United States
Missoula, Montana, United States
Lincoln, Nebraska, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
Cary, North Carolina, United States
Gastonia, North Carolina, United States
Canton, Ohio, United States
Cleveland, Ohio, United States
Tulsa, Oklahoma, United States
Tulsa, Oklahoma, United States
Portland, Oregon, United States
Pottstown, Pennsylvania, United States
Pottstown, Pennsylvania, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Knoxville, Tennessee, United States
Memphis, Tennessee, United States
Amarillo, Texas, United States
Bryan, Texas, United States
Corpus Christi, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Garland, Texas, United States
San Antonio, Texas, United States
Sherman, Texas, United States
Sherman, Texas, United States
Seattle, Washington, United States
Spokane, Washington, United States
Yakima, Washington, United States
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Weston, Ontario, Canada
Blois, , France
Cannes Cedex, , France
Chalon Sur Saone, , France
Chalon Sur Saone, , France
La Roche Sur Yon, , France
Limoges, , France
Meaux, , France
Meaux, , France
Nantes, , France
Perigueux, , France
Rennes, , France
Heidelberg, Baden Württemberg, Germany
Hamm, Nordrhein Westfalen, Germany
Aschaffenburg, , Germany
Berlin, , Germany
Berlin, , Germany
Bielefeld, , Germany
Bochum, , Germany
Dresden, , Germany
Frankfurt Oder, , Germany
Gelsenkirchen, , Germany
Goslar, , Germany
Kiel, , Germany
Ludwigsburg, , Germany
Magdeburg, , Germany
Magdeburg, , Germany
Mutlangen, , Germany
München, , Germany
Reutlingen, , Germany
Rostock, , Germany
Traunstein, , Germany
Wiesbaden, , Germany
Pesaro, Pesaro E Urbino, Italy
Ancona, , Italy
Ancona, , Italy
Cagliari, , Italy
Firenze, , Italy
Lecce, , Italy
Messina, , Italy
Messina, , Italy
Milano, , Italy
Napoli, , Italy
Napoli, , Italy
Roma, , Italy
Terni, , Italy
Torino, , Italy
Vicenza, , Italy
Truro, Cornwall, United Kingdom
Harrow, , United Kingdom
Leeds, , United Kingdom
Leeds, , United Kingdom
Manchester, , United Kingdom
Nottingham, , United Kingdom
Nottingham, , United Kingdom
Stafford, , United Kingdom
Stafford, , United Kingdom
Swansea, , United Kingdom
Urbana, Illinois, United States
Toronto, Ontario, Canada
Heidelberg, , Germany
Ludwigsburg, , Germany
Mutlangen, , Germany
Lecce, , Italy
Leeds, , United Kingdom
Saint Louis, Missouri, United States
Birmingham, Alabama, United States
Muscle Shoals, Alabama, United States
Washington, District Of Columbia, United States
Jacksonville, Florida, United States
Des Moines, Iowa, United States
Sioux City, Iowa, United States
Lexington, Kentucky, United States
London, Kentucky, United States
Shreveport, Louisiana, United States
Jackson, Mississippi, United States
Lincoln, Nebraska, United States
Cleveland, Ohio, United States
Amarillo, Texas, United States
Bryan, Texas, United States
Sherman, Texas, United States
Toronto, Ontario, Canada
Cannes Cedex, , France
Chalon Sur Saone, , France
Limoges, , France
Meaux, , France
Nantes, , France
Perigueux, , France
Rennes, , France
Aschaffenburg, , Germany
Berlin, , Germany
Bielefeld, , Germany
Dresden, , Germany
Dresden, , Germany
Frankfurt Oder, , Germany
Gelsenkirchen, , Germany
Goslar, , Germany
Kiel, , Germany
Köln, , Germany
Muenchen, , Germany
Oldenburg, , Germany
Reutlingen, , Germany
Rostock, , Germany
Rostock, , Germany
Traunstein, , Germany
Ancona, , Italy
Messina, , Italy
Roma, , Italy
Roma, , Italy
Roma, , Italy
San Giovanni Rotondo (Fg), , Italy
Harrow, , United Kingdom
Liverpool, , United Kingdom
Manchester, , United Kingdom
Stafford, , United Kingdom
Swansea, , United Kingdom
Truro, , United Kingdom
La Roche Sur Yon Cedex 9, , France
Hamm, , Germany
Magdeburg, , Germany
Wiesbaden, , Germany
Cagliari, , Italy
Firenze, , Italy
Messina, , Italy
Milano, , Italy
Napoli, , Italy
Pesaro, , Italy
Pescara, , Italy
Terni, , Italy
Torino, , Italy
Vicenza, , Italy
Nottingham, , United Kingdom
Anaheim, California, United States
Burbank, California, United States
Downey, California, United States
Fountain Valley, California, United States
Santa Rosa, California, United States
Fort Lauderdale, Florida, United States
Savannah, Georgia, United States
Valdosta, Georgia, United States
Springfield, Illinois, United States
Anderson, Indiana, United States
Indianapolis, Indiana, United States
Louisville, Kentucky, United States
Woodbury, Minnesota, United States
Kansas City, Missouri, United States
Missoula, Missouri, United States
Springfield, Missouri, United States
Omaha, Nebraska, United States
Does Not Exist, New Jersey, United States
No City Provided, New Jersey, United States
No City Provided, New Jersey, United States
No City Provided, New Jersey, United States
No City Provided, New Jersey, United States
No City Provided, New Jersey, United States
No City Provided, New Jersey, United States
Stony Brook, New York, United States
Cary, North Carolina, United States
Gastonia, North Carolina, United States
Canton, Ohio, United States
Pottstown, Pennsylvania, United States
Charleston, South Carolina, United States
Knoxville, Tennessee, United States
Memphis, Tennessee, United States
Dallas, Texas, United States
Dallas, Texas, United States
Garland, Texas, United States
San Antonio, Texas, United States
Seattle, Washington, United States
Spokane, Washington, United States
Yakima, Washington, United States
Harrow, Greater London, United Kingdom
Heidelberg, , Germany
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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