Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome

Launched by ZI-JIANG CHEN · Apr 23, 2013

Keywords

ClinConnect Summary

This will be a multi-center, prospective, randomized (1:1 ratio)clinical trial of frozen-thawed embryo transfer vs. fresh embryo transfer after a uniform gonadotropin-releasing hormone (GnRH) antagonist protocol in infertile PCOS patients receiving IVF therapy. Qualified 1180 patients are randomized into either of two groups: group A will undergo fresh embryo transfer (590 cases), Group B will undergo elective cryopreservation of all embryos followed by transfer of thawed embryos to a programmed endometrium (590 cases). All of the participants will receive recombinant follicule stimulating ...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women diagnosed as PCOS according to Chinese PCOS diagnosis criteria;
• • Women who have ≥1 years history of infertility;
• • Women aged ≥20 and \<35 years old;
• • Women with body weight ≥40kg;
• * Women who have at least one of the following indications for IVF or ICSI:
• • 1. Ovulation dysfunction and failed to become pregnant from ovulation induction treatment;
• • 2. Tubal factors: unilateral or bilateral tubal obstruction, adhesion, unilateral or bilateral Salpingectomy or tubal ligation;
• • 3. Male factors: oligoasthenozoospermia, obstructive azoospermia;
• • Women who are undergoing their first cycle of IVF or ICSI;
• • Women who retrieved oocytes number \> 3;
• • Women who are capable of giving informed consent.
• Exclusion Criteria:
• • Women who underwent unilateral ovariectomy;
• • Women diagnosed as uterus abnormality: malformed uterus (uterus unicorns, septate uterus, duplex uterus, uterus bicomis), adenomyosis, submucous myoma, intrauterine adhesion;
• • Women or their partner with abnormal chromosome karyotype including chromosome polymorphism;
• • Women who have experienced recurrent spontaneous abortion (including biochemical pregnancy abortion) more than 2 times;
• • Women with medical condition that represent contraindication to assisted reproductive technology and/or pregnancy;
• • Women who has developed severe OHSS before oocyte pick-up day;
• • Women with retrieved oocytes number ≤3;
• • Women who are unable to comply with the study procedures.