Image-Guided Adaptive Radiotherapy for in Detecting Tumors During Treatment in Patients With Head and Neck Cancer

Launched by VIRGINIA COMMONWEALTH UNIVERSITY · Apr 26, 2013

Keywords

ClinConnect Summary

I. To conduct a clinical imaging study utilizing three novel in-room imaging systems: Oblique Brainlab ExacTrac images, Orthogonal Varian kilovoltage (kV) On-board Imaging (OBI) image, and Varian cone-beam computed tomography (CBCT) imaging to assess their performance in reducing inter- and intrafractional setup errors, relative to weekly megavoltage (MV) electronic portal imaging device (EPID) images, using both bony landmarks and soft tissue changes for head and neck cancer (HNC) patients undergoing external beam radiation therapy (RT).

II. To assess the accuracy of CBCT imaging for meas...

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Eligibility criteria

• Inclusion Criteria:
• • Histologic or cytologic confirmation of head and neck malignancy
• • Patients who will be treated with definitive radiation therapy or concurrent chemoradiation therapy
• • Gross tumor volume (GTV) must be visible on CT
• • All patients must be informed of the investigational nature of this study and must give written informed consent in accordance with institutional and federal guidelines
• Exclusion Criteria:
• • Pregnant or nursing women may not participate; women of reproductive potential must be offered a pre-treatment pregnancy test and informed of the need to practice an effective contraceptive method
• • Prior treatment with radiation therapy to the head and neck
• • Serum creatinine \> 1.5 and/or
• • Blood urea nitrogen \[BUN\] \> 25
• • Treatment with any prior chemotherapy or surgery (excluding diagnostic biopsy) for this malignancy
• • Patients with known syndromes expected to alter radiosensitivity (e.g. ataxia-telangiectasia, scleroderma, lupus, human immunodeficiency virus \[HIV\]/acquired immunodeficiency deficiency syndrome \[AIDS\]) may not participate