EndoBarrier Versus Intragastric Balloon in Obese Diabetic Patients

Launched by THE MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES · May 3, 2013

Keywords

ClinConnect Summary

Bariatric surgery is an effective therapy for obesity. Malabsorption-based surgical techniques (excluding the first part of the gastrointestinal tract from the alimentary circuit) are also effective in correcting T2D, even before any significant weight loss has occurred. Proposed mechanisms to explain this beneficial effect include caloric restriction, altered secretion of gut hormones due to duodenal exclusion or due to contact of undigested food with the jejunal mucosa, pancreatic islet hyperfunction, changes of intestinal flora, mucosal inflammation, and/or changes in the biliary acid re...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (18-60 year old)
• • Type 2 Diabetes diagnosed less than 10 years ago
• • Obesity (BMI \> 30)
• Exclusion Criteria:
• • pregnancy
• • inflammatory bowel disease
• • peptic ulcer
• • gastrointestinal disease preventing device positioning
• • pancreatitis,
• • coronary artery disease
• • symptomatic pulmonary disease
• • infection at the time of device placement,
• • high risk of gastrointestinal bleeding (coagulopathy, bleeding diathesis, anti-coagulant therapy, Non-Steroid Anti-Inflammatory Drugs)
• • altered GI anatomy that could affect device placement
• • contraindication of positioning of the devices as per technical description of the producer
• • C-peptide negative diabetes
• • failure to understand the study protocol or not willing to undergo planned follow-up