Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

Launched by UNIVERSITY OF FLORIDA · May 7, 2013

Keywords

ClinConnect Summary

This clinical trial is investigating how two lung conditions, Alpha-1 Antitrypsin Deficiency (AATD) and Cystic Fibrosis (CF), affect white blood cells in the lungs called macrophages. These cells play a crucial role in fighting infections and maintaining lung health. By understanding how these diseases impact the function of macrophages, researchers hope to learn more about the underlying causes of lung problems in patients with AATD and CF.

To participate in this trial, you need to be at least 18 years old and able to give your consent to join. Women who can become pregnant must have a negative pregnancy test. Key health requirements include having a certain level of hemoglobin in your blood and not being a current smoker. Participants will be asked to provide some health information and may undergo tests to ensure they meet the eligibility criteria. This trial is currently recruiting participants, and taking part could contribute to important research that may improve the understanding and treatment of these lung diseases.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed informed consent
• • Male or female 18 years of age or older
• • Negative pregnancy test for women of childbearing potential
• • Hemoglobin \>12.5 g/dl measured on the day of participation
• • Negative urine nicotine test
• Exclusion Criteria:
• • Pregnancy or breastfeeding
• • Weight \< 50 kg
• • History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months
• • Known hemoglobin \<12.5 g/dl within the past 90 days
• • Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \>100 mmHg
• • Poor venous access
• • Large volume blood donation (\>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)
• • Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)
• • Psychiatric or cognitive disturbance or illness that would affect subject safety
• • Current smoker