Ovarian Tissue Transplantation

Launched by ABRAMSON CANCER CENTER AT PENN MEDICINE · Jun 4, 2013

Keywords

ClinConnect Summary

This clinical trial is studying a procedure called ovarian tissue transplantation, which aims to help women who are infertile or have low ovarian function after undergoing cancer treatments like chemotherapy or radiation. The researchers want to find out if transplanting previously frozen ovarian tissue back into a woman's body can safely restore her ability to conceive. This experimental approach is being offered at The University of Pennsylvania, and they are currently looking for participants to join the study.

To be eligible for this trial, women need to be between 18 and 45 years old and have ovarian tissue that was frozen and stored for this purpose. They should also have been diagnosed with ovarian insufficiency, which means their hormone levels indicate their ovaries are not functioning properly, and they should have been unable to conceive after trying for six months without protection. Participants need to be in reasonably good health and have their oncologist's approval for the procedure. Those who may be at high risk for surgery or have certain medical conditions will not be able to participate. If you join this trial, you can expect to undergo the transplantation procedure and help researchers learn more about its effectiveness and safety for future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female patient between the ages of 18 and 45 years
• • Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
• • Ovarian insufficiency defined as an elevated FSH over 10
• • Inability to conceive after 6 months of unprotected intercourse with male
• • Reasonably good health
• • Candidate for pregnancy
• • Written clearance for the procedure from the patients oncologist
• Exclusion Criteria:
• • Patients considered to be high risk for surgical complications will be excluded from the research protocol
• • Women who are known to be positive for the BRCA mutation
• • Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
• • Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
• • Current pregnancy