Can High Convection Volumes be Achieved in Each Patient During Online Post-dilution Hemodiafiltration?

Launched by AMSTERDAM UMC, LOCATION VUMC · Jun 10, 2013

Keywords

ClinConnect Summary

Hemodialysis (HD) is the most common used renal replacement therapy worldwide. The main objective is the removal of excess fluid and toxic solutes from the patient. Despite the relative efficiency of modern dialyzers, HD remains inferior to normal kidney function, in part because of the inadequate clearance of so-called 'middle molecules'. In other words, 'uremic toxins' accumulate in chronic HD patients.

The role of middle molecular weight uremic toxins in the pathogenesis of many co-morbid conditions associated with end-stage renal disease is increasingly recognized. Hence, the hypothesi...

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Eligibility criteria

• Inclusion Criteria:
• • Patients treated with HD or HDF since \>6 weeks, 3 times a week;
• • Patients able to understand the study procedures;
• • Patients willing to provide written informed consent.
• Exclusion Criteria:
• • Current age \< 18 years;
• • Severe incompliance to dialysis procedure and accompanying prescriptions (frequency and duration of dialysis treatment and fluid restriction);
• • Life expectancy \< 3 months due to non-renal disease.