Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction

Launched by ALEXANDRIA UNIVERSITY · Jun 12, 2013

Keywords

ClinConnect Summary

Bioactive glass has long been known as a bone graft substitute capable of bone augmentation. The current proposal introduces a newly tailored bioactive glass scaffold with multi-scale porosity prepared using the sol-gel technique to regenerate bone in extraction sockets with the aim of preserving the alveolar ridge. This novel material has the potential to enhance angiogenesis and osteogenesis thereby preserving the overall height and width of the alveolar bone by regenerating new bone that closely mimics the adjacent healthy one. Thirty patients requiring myofunctional therapy including pr...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must have good oral hygiene (confirmed by OHI-S)
• • Patients who had voluntarily agreed on signing an informed consent including the duration and all the steps of the trial
• • Patients who are indicated for the administration of the type of local anesthesia used in the trial
• • Patients who need myofunctional therapy including premolar extraction as part of two stage treatment (class II division I)
• • Patients indicated for premolar extraction as a normal step in the treatment plan not intentionally for the experiment.
• • Patients who had undergone x- rays on the premolar teeth showing root form and the shape of the socket prior to extraction
• Exclusion Criteria:
• • Patients with history of bleeding disorders which will hinder the normal healing process of the needed sockets for the trial
• • Patients with history of allergy to foreign bodies , i.e. susceptible to reactions from Bioglass
• • Patients with history of hypertension and diabetes , rendering them not indicated for administration of the recommended type of local anesthesia nor even for extraction
• • Patients having HCV , HBV , HIV or other infectious diseases to make sure of the safety of the research team and the participants from probable infection .
• • Mentally retarded patients who are not able to understand the steps of the trial Patients with systemic diseases or febrile illness making them unable to follow the appointments arranged
• • Patients who simultaneously participate in other research studies
• • Patients with traumatic surgical extraction

Trial Officials