Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Jun 17, 2013

Keywords

ClinConnect Summary

This clinical trial is comparing two different methods for checking for cancer in patients who have had ulcerative colitis for a long time. Ulcerative colitis is a condition that can increase the risk of colon cancer, especially after eight years from when it was first diagnosed. Currently, doctors follow guidelines that recommend taking many tissue samples during exams to look for cancer signs. However, this study aims to see if newer imaging techniques, like Narrow-Band Imaging (NBI) and Fujinon Intelligent Chromo-Endoscopy (FICE), are just as effective as the traditional method called chromo-endoscopy, but potentially easier and quicker.

To participate in this trial, individuals must have had ulcerative colitis for at least eight years, have had a previous endoscopy in the last year, and be able to give their consent. Unfortunately, people with active ulcerative colitis, a history of colon cancer, or those who are pregnant cannot take part. If eligible, participants can expect to undergo an endoscopic examination where doctors will use different imaging techniques to look for any signs of cancer, helping to improve future cancer screening methods for those with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with longstanding ulcerative colitis ( 8 years after diagnosis or pancolitis and 10 years after diagnosis of left-sided colitis)
• • Signed informed consent form
• • Previous surveillance endoscopy \> 1 year
• Exclusion Criteria:
• • Active ulcerative colitis, \> 20 cm from the margo ani
• • Personal history of colorectal cancer
• • Allergy or intolerance to methylene blue
• • Refusing or incapable to agree with informed consent
• • Age younger than 18 years
• • Pregnant women