Hormonal, Metabolic, and Signaling Interactions in PAH

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jun 18, 2013

Keywords

ClinConnect Summary

This clinical trial is studying how certain hormone and metabolic changes in the body can affect pulmonary arterial hypertension (PAH), a serious condition that affects blood flow in the lungs. The researchers believe that treating these metabolic issues might help improve lung function and overall health for people with different types of PAH. The trial is currently looking for participants of all ages, from newborns to those up to 90 years old, who have been diagnosed with idiopathic PAH, heritable PAH, or PAH associated with other conditions, as well as family members of affected individuals.

If you or a family member are interested in participating, you will need to meet specific criteria, such as having one of the eligible types of PAH and being able to visit the clinic for various tests. Participants will undergo blood tests and may need to fast for a period before some tests. This trial aims to gather important information that could lead to better treatments for PAH in the future. Your involvement could help advance understanding of this condition and how to manage it more effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Project 1
• Inclusion:
• • 1. Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons
• • 2. Age 0-90, age 12-90 for skin biopsy
• Exclusion:
• • 1. Other diagnosis
• • 2. Age greater than 90, age less than 12 or greater than 90 for skin biopsy
• • Project 2
• Inclusion:
• • 1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
• • 2. 0-90
• • 3. Subjects with reasonably easy access to clinic for blood collection and other testing
• • 4. Subject able to tolerate fasting state prior to sample collection and EndoPAT (endothelial function assessment) testing
• Exclusion:
• • 1. Other diagnosis
• • 2. 0-90
• • 3. Subjects with difficulty reaching clinic for blood collection and other testing
• • 4. Subjects unable to tolerate fasting state
• • Project 3
• Inclusion:
• • 1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
• • 2. 7-90
• Exclusion:
• • 1. Other diagnosis
• • 2. Age less than 7 or greater than 90
• • -
• Exclusion Criteria:
• • -