Comparison of Axillary Lymph Node Dissection with Axillary Radiation for Patients with Node-Positive Breast Cancer Treated with Chemotherapy
Launched by ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY · Jul 15, 2013
Trial Information
Current as of July 08, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating two different ways to treat breast cancer that has spread to nearby lymph nodes after patients have received chemotherapy and surgery. The two treatments being compared are axillary lymph node dissection, which is a surgery to remove lymph nodes that may contain cancer, and radiation therapy, which uses high-energy rays to kill cancer cells. Researchers want to find out which treatment works better for patients who have already undergone chemotherapy.
To be eligible for this trial, participants should have certain types of breast cancer (stages II or IIIA) and must have had evidence of cancer in their lymph nodes through a biopsy. They should not have inflammatory breast cancer or other active cancers, and they must have completed their chemotherapy before joining the study. If selected, participants will receive either the surgery or radiation therapy as part of their treatment plan. The trial is currently active but not recruiting new participants. It is important for potential participants to discuss their eligibility and treatment options with their healthcare provider.
Gender
ALL
Eligibility criteria
- Pre-Registration Eligibility Criteria:
- • Clinical stage T1-3 N1 M0 breast cancer at diagnosis (prior to the start of neoadjuvant chemotherapy) by American Joint Committee on Cancer (AJCC) staging 7th edition
- • No inflammatory breast cancer
- • No other malignancy within 5 years of registration with the exception of basal cell or squamous cell carcinoma of the skin treated with local resection only or carcinoma in situ of the cervix
- • All patients must have had an axillary ultrasound with fine needle aspiration (FNA) or core needle biopsy of axillary lymph nodes documenting axillary metastasis at the time of diagnosis, prior to or at most 14 days after starting neoadjuvant chemotherapy
- • \* Note: Biopsy of intramammary nodes does not fulfill eligibility criteria
- • Patients must have had estrogen receptor, progesterone receptor and HER2 status (by immunohistochemistry \[IHC\] and/or in situ hybridization \[ISH\]) evaluated on diagnostic core biopsy prior to start of neoadjuvant chemotherapy
- • \* Note: If HER2 status has not been clearly determined (i.e. equivocal/indeterminate), then patients should not be enrolled
- • Patients must have completed all planned neoadjuvant chemotherapy prior to surgery; sandwich chemotherapy is not allowed (i.e. anthracycline/cytoxan or taxane chemotherapy planned to be given after surgery); patients must have completed at least 4 cycles of neoadjuvant chemotherapy consisting of an anthracycline and/or taxane-based regimen without evidence of disease progression in the breast or the lymph nodes
- • \* Note: Delays/dose modifications due to toxicities/adverse events are allowed as long as a minimum of 4 cycles of neoadjuvant chemotherapy is administered; more than 4 cycles of neoadjuvant chemotherapy (NAC) may be administered at the discretion of the treating medical oncologist
- • Patients with HER-2 positive tumors must have received neoadjuvant trastuzumab, or trastuzumab + pertuzumab, or other approved anti-HER-2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen); therapy must be Food and Drug Administration (FDA)-approved targeted anti-HER2 therapy, but additional therapies are allowed as are non-trastuzumab regimens if administered in the context of an Institutional Review Board (IRB)-approved clinical trial
- • All patients must have a clinically negative axilla (no bulky adenopathy) on physical examination documented at the completion of neoadjuvant chemotherapy
- • \* Note: an ultrasound of the axilla is not required at completion of neoadjuvant chemotherapy; if performed, its findings do NOT impact eligibility
- • No more than 8 weeks of neoadjuvant endocrine therapy prior to the start of neoadjuvant chemotherapy
- • No neoadjuvant radiation therapy
- • No SLN surgery/excisional biopsy for pathological confirmation of axillary status prior to or during neoadjuvant chemotherapy
- • No prior history of ipsilateral breast cancer (invasive disease or ductal carcinoma in situ \[DCIS\]); lobular carcinoma in situ (LCIS) and benign breast disease is allowed
- • No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or treatment of hidradenitis
- • No history of prior or concurrent contralateral invasive breast cancer; benign breast disease; LCIS or DCIS of contralateral breast is allowed
- • Patients must not be pregnant or nursing
- • \* Note: Peri-menopausal women must be amenorrheic for \> 12 months to be considered not of childbearing potential
- • Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1
- Intra-Operative Registration/Randomization Criteria:
- • Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be completed within 56 days of the completion of the last dose of neoadjuvant chemotherapy
- • A minimum of 1 sentinel node and a maximum of 8 total nodes (sentinel + non-sentinel) are identified and excised; more than 8 nodes identified by either surgeon or pathologist is NOT allowed Note: Patients who do not have an identifiable sentinel lymph node will not proceed to registration/randomization
- • At least one lymph node (sentinel or non-sentinel) excised during sentinel lymph node surgery with a metastasis greater than 0.2 mm in greatest dimension identified on intra-operative pathologic assessment
- • Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated as node negative disease (N0i+)
- • Note: If on final pathology, more than 8 lymph nodes are seen pathologically, then the patient should discontinue study
- • Axillary lymph node dissection (ALND) is not to be performed prior to registration/randomization
- • Note: Patients for whom no positive lymph nodes (sentinel or non-sentinel) are found during sentinel lymph node surgery will not proceed to registration/randomization and can be considered for discussion of the NRG NSABP B-51/RTOG 1304 study "A Randomized Phase III Clinical Trial Evaluating the Role of Post-mastectomy Chest Wall and Regional Nodal XRT and Post-lumpectomy Regional Nodal XRT in Patients with Documented Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy"
- Post-Operative Registration/Randomization Criteria:
- • For cases where ALND has not been performed and one of the following is true: 1) intra-operative evaluation of sentinel lymph node could not be/was not performed and final pathology identified a positive lymph node (sentinel or non-sentinel) with metastasis greater than 0.2 mm OR 2) lymph node (sentinel or non-sentinel) considered negative on intra-operative evaluation was found to be positive on final pathology (with metastasis greater than 0.2 mm)
- • Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be completed within 56 days of the completion of the last dose of neoadjuvant chemotherapy; negative margin (by either breast conservation or mastectomy) on final pathology where negative margin is defined as no tumor on ink
- • At least one lymph node (sentinel or non-sentinel) with a metastasis greater than 0.2 mm in greatest dimension identified on final pathology (for cases where intra-operative evaluation was not performed, or was negative and completion dissection was not performed)
- • At least one and no more than 8 lymph nodes (sentinel and non-sentinel) were found by the pathologists to have been actually excised during sentinel lymph node procedure Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated as node negative disease (N0i+)
- • For those patients who also undergo contralateral breast surgery, if invasive disease is found in the contralateral breast, the patient is not eligible for registration /randomization
About Alliance For Clinical Trials In Oncology
The Alliance for Clinical Trials in Oncology is a prominent cooperative group dedicated to conducting high-quality, innovative clinical research aimed at improving cancer treatment and patient outcomes. Comprising a diverse network of institutions and investigators, the Alliance focuses on developing and implementing clinical trials that evaluate new therapies, treatment combinations, and prevention strategies across various cancer types. By fostering collaboration among oncologists, researchers, and healthcare professionals, the Alliance aims to accelerate the translation of scientific discoveries into effective clinical practices, ultimately enhancing the standard of care for cancer patients.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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Atlanta, Georgia, United States
Grand Island, Nebraska, United States
Carmel, Indiana, United States
Fort Smith, Arkansas, United States
Burlingame, California, United States
Truckee, California, United States
Vallejo, California, United States
Colorado Springs, Colorado, United States
Edwards, Colorado, United States
Lakeland, Florida, United States
Post Falls, Idaho, United States
Bloomington, Illinois, United States
Chicago, Illinois, United States
Geneva, Illinois, United States
Pekin, Illinois, United States
Hays, Kansas, United States
Liberal, Kansas, United States
Towson, Maryland, United States
Bay City, Michigan, United States
Flint, Michigan, United States
Mankato, Minnesota, United States
Bolivar, Missouri, United States
Branson, Missouri, United States
Saint Louis, Missouri, United States
New York, New York, United States
Concord, North Carolina, United States
Oklahoma City, Oklahoma, United States
Bend, Oregon, United States
Erie, Pennsylvania, United States
Erie, Pennsylvania, United States
Harrisburg, Pennsylvania, United States
Kittanning, Pennsylvania, United States
Warwick, Rhode Island, United States
Boiling Springs, South Carolina, United States
Easley, South Carolina, United States
Georgetown, South Carolina, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Greenwood, South Carolina, United States
Greer, South Carolina, United States
Seneca, South Carolina, United States
Poulsbo, Washington, United States
Spokane, Washington, United States
Parkersburg, West Virginia, United States
Burlington, Wisconsin, United States
Germantown, Wisconsin, United States
Green Bay, Wisconsin, United States
Kenosha, Wisconsin, United States
Marinette, Wisconsin, United States
Milwaukee, Wisconsin, United States
Milwaukee, Wisconsin, United States
Racine, Wisconsin, United States
Summit, Wisconsin, United States
Two Rivers, Wisconsin, United States
Waukesha, Wisconsin, United States
Wauwatosa, Wisconsin, United States
San Juan, , Puerto Rico
Auburn, California, United States
Cameron Park, California, United States
Roseville, California, United States
Vacaville, California, United States
Peoria, Illinois, United States
Fort Wayne, Indiana, United States
Saint Johnsbury, Vermont, United States
Vancouver, Washington, United States
Nashville, Tennessee, United States
South Pasadena, California, United States
Teaneck, New Jersey, United States
Newark, Delaware, United States
York, Pennsylvania, United States
Mckeesport, Pennsylvania, United States
Fredericksburg, Virginia, United States
Fitchburg, Massachusetts, United States
Kansas City, Missouri, United States
Los Angeles, California, United States
Gettysburg, Pennsylvania, United States
Hanover, Pennsylvania, United States
Fairbanks, Alaska, United States
Scottsdale, Arizona, United States
Hot Springs, Arkansas, United States
Arroyo Grande, California, United States
Vacaville, California, United States
Whittier, California, United States
Stuart, Florida, United States
Stuart, Florida, United States
Anderson, Indiana, United States
Goshen, Indiana, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Olathe, Kansas, United States
Owensboro, Kentucky, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Jefferson City, Missouri, United States
Omaha, Nebraska, United States
Pennington, New Jersey, United States
Santa Fe, New Mexico, United States
Hendersonville, North Carolina, United States
Cincinnati, Ohio, United States
Oklahoma City, Oklahoma, United States
Erie, Pennsylvania, United States
Meadowbrook, Pennsylvania, United States
Nashville, Tennessee, United States
Bryan, Texas, United States
Longview, Washington, United States
Bridgeport, West Virginia, United States
Appleton, Wisconsin, United States
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Quebec City, Quebec, Canada
Saint Joseph, Missouri, United States
Antioch, California, United States
Emeryville, California, United States
Fresno, California, United States
Modesto, California, United States
Oakland, California, United States
Rancho Cordova, California, United States
Roseville, California, United States
South San Francisco, California, United States
Sunnyvale, California, United States
Atlanta, Georgia, United States
Honolulu, Hawaii, United States
Lihue, Hawaii, United States
Fruitland, Idaho, United States
Lewiston, Idaho, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Twin Falls, Idaho, United States
West Des Moines, Iowa, United States
Great Bend, Kansas, United States
Overland Park, Kansas, United States
Baton Rouge, Louisiana, United States
New Orleans, Louisiana, United States
Bel Air, Maryland, United States
Farmington Hills, Michigan, United States
Kansas City, Missouri, United States
Kansas City, Missouri, United States
Lee's Summit, Missouri, United States
Rolla, Missouri, United States
Rolla, Missouri, United States
Monroe, North Carolina, United States
Shelby, North Carolina, United States
Fargo, North Dakota, United States
Beachwood, Ohio, United States
Chardon, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Middleburg Heights, Ohio, United States
Parma, Ohio, United States
Portsmouth, Ohio, United States
Sandusky, Ohio, United States
Oregon City, Oregon, United States
Monroeville, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Rock Hill, South Carolina, United States
Fredericksburg, Virginia, United States
Anacortes, Washington, United States
Bellevue, Washington, United States
Burien, Washington, United States
Edmonds, Washington, United States
Everett, Washington, United States
Issaquah, Washington, United States
Lacey, Washington, United States
New Richmond, Wisconsin, United States
Barrie, Ontario, Canada
Urbana, Illinois, United States
Randallstown, Maryland, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Columbus, Ohio, United States
Delaware, Ohio, United States
Brooklyn, New York, United States
Longmont, Colorado, United States
Las Vegas, Nevada, United States
Monroeville, Pennsylvania, United States
Springfield, Ohio, United States
Lubbock, Texas, United States
Saint Peters, Missouri, United States
Beaver, Pennsylvania, United States
Greensburg, Pennsylvania, United States
Johnstown, Pennsylvania, United States
Moon, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Uniontown, Pennsylvania, United States
Washington, Pennsylvania, United States
Anchorage, Alaska, United States
Loveland, Colorado, United States
Sugar Land, Texas, United States
Auburn, California, United States
Santa Cruz, California, United States
Newark, Delaware, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Wilmington, Delaware, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Emmett, Idaho, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Sandpoint, Idaho, United States
Fort Wayne, Indiana, United States
Mishawaka, Indiana, United States
Clive, Iowa, United States
West Des Moines, Iowa, United States
Garden City, Kansas, United States
Great Bend, Kansas, United States
Lenexa, Kansas, United States
Lenexa, Kansas, United States
Manhattan, Kansas, United States
Brighton, Michigan, United States
Brighton, Michigan, United States
Canton, Michigan, United States
Canton, Michigan, United States
Caro, Michigan, United States
Chelsea, Michigan, United States
Chelsea, Michigan, United States
Clarkston, Michigan, United States
Clarkston, Michigan, United States
East China Township, Michigan, United States
Farmington Hills, Michigan, United States
Flint, Michigan, United States
Flint, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Livonia, Michigan, United States
Macomb, Michigan, United States
Macomb, Michigan, United States
Marlette, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Rochester Hills, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
West Branch, Michigan, United States
Ypsilanti, Michigan, United States
Ypsilanti, Michigan, United States
Minneapolis, Minnesota, United States
Anaconda, Montana, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Clinton, North Carolina, United States
Jacksonville, North Carolina, United States
Centerville, Ohio, United States
Delaware, Ohio, United States
Dublin, Ohio, United States
Grove City, Ohio, United States
Marion, Ohio, United States
West Chester, Ohio, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
Lewisburg, Pennsylvania, United States
South Jordan, Utah, United States
Cody, Wyoming, United States
Cody, Wyoming, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Durango, Colorado, United States
Golden, Colorado, United States
Lakewood, Colorado, United States
Parker, Colorado, United States
Pueblo, Colorado, United States
Thornton, Colorado, United States
Creston, Iowa, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
Commack, New York, United States
Flushing, New York, United States
Hampton, Virginia, United States
Aberdeen, Washington, United States
Bellevue, Washington, United States
Seattle, Washington, United States
Shelton, Washington, United States
Yelm, Washington, United States
Boulder, Colorado, United States
Denver, Colorado, United States
Englewood, Colorado, United States
Greenwood Village, Colorado, United States
Littleton, Colorado, United States
Lone Tree, Colorado, United States
Altamonte Springs, Florida, United States
Kissimmee, Florida, United States
Orlando, Florida, United States
Orlando, Florida, United States
Winter Park, Florida, United States
Savannah, Georgia, United States
Savannah, Georgia, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Danville, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
New Lenox, Illinois, United States
O'fallon, Illinois, United States
Ottawa, Illinois, United States
Swansea, Illinois, United States
Yorkville, Illinois, United States
Michigan City, Indiana, United States
Crestview Hills, Kentucky, United States
Louisville, Kentucky, United States
Brownstown, Michigan, United States
Clinton Township, Michigan, United States
West Bloomfield, Michigan, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Bonne Terre, Missouri, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Asheville, North Carolina, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Huntersville, North Carolina, United States
Huntersville, North Carolina, United States
Matthews, North Carolina, United States
Mebane, North Carolina, United States
Mooresville, North Carolina, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Fairfield, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Middletown, Ohio, United States
Sidney, Ohio, United States
Troy, Ohio, United States
Clackamas, Oregon, United States
Conroe, Texas, United States
Houston, Texas, United States
League City, Texas, United States
Seattle, Washington, United States
Spokane Valley, Washington, United States
Spokane, Washington, United States
Spokane, Washington, United States
Fond Du Lac, Wisconsin, United States
Cheyenne, Wyoming, United States
Montvale, New Jersey, United States
Harrison, New York, United States
Uniondale, New York, United States
Middletown, New Jersey, United States
Dublin, California, United States
Glenview, Illinois, United States
Highland Park, Illinois, United States
Lincoln, Nebraska, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Basking Ridge, New Jersey, United States
Richmond, Virginia, United States
Jonesboro, Arkansas, United States
Bakersfield, California, United States
Clovis, California, United States
Dublin, California, United States
Fresno, California, United States
Sacramento, California, United States
San Rafael, California, United States
Walnut Creek, California, United States
Denver, Colorado, United States
Newburgh, Indiana, United States
Westminster, Maryland, United States
South Weymouth, Massachusetts, United States
Norton Shores, Michigan, United States
Novi, Michigan, United States
Monticello, Minnesota, United States
Columbus, Mississippi, United States
Grenada, Mississippi, United States
New Albany, Mississippi, United States
Oxford, Mississippi, United States
Southhaven, Mississippi, United States
Creve Coeur, Missouri, United States
Saint Louis, Missouri, United States
Carson City, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Reno, Nevada, United States
Sleepy Hollow, New York, United States
Jacksonville, North Carolina, United States
Supply, North Carolina, United States
Ravenna, Ohio, United States
Broomall, Pennsylvania, United States
Ephrata, Pennsylvania, United States
Lebanon, Pennsylvania, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Lancaster, South Carolina, United States
Rock Hill, South Carolina, United States
Memphis, Tennessee, United States
League City, Texas, United States
Riverton, Utah, United States
Gig Harbor, Washington, United States
Appleton, Wisconsin, United States
Brookfield, Wisconsin, United States
Eau Claire, Wisconsin, United States
Franklin, Wisconsin, United States
Oshkosh, Wisconsin, United States
Stevens Point, Wisconsin, United States
Wyandotte, Michigan, United States
Indianapolis, Indiana, United States
Honolulu, Hawaii, United States
Wexford, Pennsylvania, United States
Farmington, Utah, United States
Bainbridge Island, Washington, United States
Federal Way, Washington, United States
Gig Harbor, Washington, United States
Kennewick, Washington, United States
Lynnwood, Washington, United States
Port Townsend, Washington, United States
Poulsbo, Washington, United States
Puyallup, Washington, United States
Tacoma, Washington, United States
Tacoma, Washington, United States
Milwaukee, Wisconsin, United States
'Aiea, Hawaii, United States
Scottsdale, Arizona, United States
Scottsdale, Arizona, United States
Atlantis, Florida, United States
Avon, Indiana, United States
Emporia, Kansas, United States
Garden City, Kansas, United States
Kenner, Louisiana, United States
Rockport, Maine, United States
Sewell, New Jersey, United States
Carmel, New York, United States
Fishkill, New York, United States
Kingston, New York, United States
Asheville, North Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Mount Pleasant, South Carolina, United States
Arlington, Texas, United States
Bedford, Texas, United States
Denison, Texas, United States
Flower Mound, Texas, United States
Grapevine, Texas, United States
Plano, Texas, United States
Sugar Land, Texas, United States
Kennewick, Washington, United States
Appleton, Wisconsin, United States
Menomonee Falls, Wisconsin, United States
West Bend, Wisconsin, United States
'Aiea, Hawaii, United States
Albuquerque, New Mexico, United States
Trumbull, Connecticut, United States
Des Moines, Iowa, United States
Overland Park, Kansas, United States
Westwood, Kansas, United States
Kernersville, North Carolina, United States
Mount Airy, North Carolina, United States
Thomasville, North Carolina, United States
Wilkesboro, North Carolina, United States
Peoria, Arizona, United States
Columbia, Maryland, United States
Albert Lea, Minnesota, United States
Westlake, Ohio, United States
Midlothian, Virginia, United States
Orland Park, Illinois, United States
Plainfield, Illinois, United States
Glen Burnie, Maryland, United States
Charlotte, North Carolina, United States
Providence, Rhode Island, United States
Mckinney, Texas, United States
Mobile, Alabama, United States
North Kansas City, Missouri, United States
Jefferson Hills, Pennsylvania, United States
Aiea, Hawaii, United States
Phoenix, Arizona, United States
San Luis Obispo, California, United States
Santa Maria, California, United States
Boulder, Colorado, United States
Tawas City, Michigan, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Rio Rancho, New Mexico, United States
Perrysburg, Ohio, United States
Willow Grove, Pennsylvania, United States
Brewer, Maine, United States
Roseville, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Sterling Heights, Michigan, United States
Sterling Heights, Michigan, United States
Troy, Michigan, United States
Troy, Michigan, United States
Troy, Michigan, United States
Seattle, Washington, United States
Rock Hill, South Carolina, United States
Gilbert, Arizona, United States
Phoenix, Arizona, United States
Surprise, Arizona, United States
Seattle, Washington, United States
Norfolk, Virginia, United States
Fairfield, Connecticut, United States
Guilford, Connecticut, United States
North Haven, Connecticut, United States
Waterford, Connecticut, United States
Dekalb, Illinois, United States
Fort Thomas, Kentucky, United States
Mount Pleasant, Michigan, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Charleston, South Carolina, United States
Bayamon, , Puerto Rico
Manati, , Puerto Rico
Statesville, North Carolina, United States
Beaumont, Texas, United States
Greenwich, Connecticut, United States
New Haven, Connecticut, United States
Baton Rouge, Louisiana, United States
Germantown, Tennessee, United States
Memphis, Tennessee, United States
Colorado Springs, Colorado, United States
Corona, California, United States
Honolulu, Hawaii, United States
Ballwin, Missouri, United States
Wpafb, Ohio, United States
Daphne, Alabama, United States
Mobile, Alabama, United States
Mobile, Alabama, United States
Denver, Colorado, United States
Golden, Colorado, United States
Thornton, Colorado, United States
Honolulu, Hawaii, United States
Royal Oak, Michigan, United States
Round Rock, Texas, United States
Grand Junction, Colorado, United States
Royal Oak, Michigan, United States
Mechanicsville, Virginia, United States
'Aiea, Hawaii, United States
Neenah, Wisconsin, United States
Oak Creek, Wisconsin, United States
Tampa, Florida, United States
Chadds Ford, Pennsylvania, United States
Libertyville, Illinois, United States
Northfield, Minnesota, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Glendale, Arizona, United States
Redwood City, California, United States
San Mateo, California, United States
Santa Cruz, California, United States
Santa Rosa, California, United States
Tarzana, California, United States
Upland, California, United States
Colorado Springs, Colorado, United States
Englewood, Colorado, United States
Fort Collins, Colorado, United States
Greeley, Colorado, United States
Frankford, Delaware, United States
Tampa, Florida, United States
Lafayette, Indiana, United States
Peabody, Massachusetts, United States
Burnsville, Minnesota, United States
Lincoln, Nebraska, United States
Greensboro, North Carolina, United States
Wilmington, North Carolina, United States
Lewisburg, Pennsylvania, United States
York, Pennsylvania, United States
Lancaster, South Carolina, United States
Memphis, Tennessee, United States
Salt Lake City, Utah, United States
Richmond, Virginia, United States
Virginia Beach, Virginia, United States
Chilton, Wisconsin, United States
Franklin, Wisconsin, United States
Nampa, Idaho, United States
West Harrison, New York, United States
East China, Michigan, United States
Macomb Township, Michigan, United States
Macomb Township, Michigan, United States
Moon Township, Pennsylvania, United States
Aiea, Hawaii, United States
Aiea, Hawaii, United States
Aiea, Hawaii, United States
Canandiaqua, New York, United States
Stateville, North Carolina, United States
Patients applied
Trial Officials
Judy Boughey, MD
Study Chair
Mayo Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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