Effects of Triacylglycerol Structure on Gut Hormones and Haemostatic Markers

Launched by MALAYSIA PALM OIL BOARD · Jul 19, 2013

Keywords

ClinConnect Summary

Subjects aged between 30 and 60 years old (male and female) with Type 2 diabetes mellitus (T2DM) will be recruited for this study. A randomized, crossover, double-blind study design will be carried out to investigate the acute effects of high fat meals prepared using palm olein (PO), chemically interesterified palm olein (IPO) and high oleic sunflower oil (HOS) (control) on study subjects with T2DM. Study subjects will have to undergo three postprandial challenges, separated by at least one week interval. Fasting blood sample and duplicate baseline blood samples will be taken in the morning...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Mild T2DM individuals not planned for medical intervention
• • 7.0 mmol/L ≤ fasting glucose ≤ 11.1 mmol/L
• • 6.5% ≤ HbA1c ≤ 9.0%
• • Not using antihypertensive, lipid lowering, insulin/glucose modulating medication
• • 2. Mild T2DM individuals currently on medical intervention
• • Fasting glucose ≤ 11.1 mmol/L
• • HbA1c ≤ 9.0%
• • Using antihypertensive, lipid lowering or glucose modulating medication
• • 3. Malaysian male or female with T2DM aged between 30 to 60 years old
• • 4. Not using insulin
• • 5. Not having any complications of diabetes
• • 6. No medical history of myocardial infarction, angina, thrombosis, stroke or cancer
• • 7. Haemoglobin levels for females ≥ 11.5 gm/dl and males ≥ 12.5 gm/dl
• • 8. Serum ferritin \> 15 µg/l at commencement of study
• Exclusion Criteria:
• • 1. Medical history of myocardial infarction, angina, thrombosis, stroke or cancer
• • 2. Underweight (BMI \< 18.5 kg/m²)
• • 3. Using insulin
• • 4. Total cholesterol \> 7.0 mmol/L
• • 5. Abnormal liver function, renal function and haematology
• • 6. Hypersensitive towards heparin
• • 7. Gastric or lactose intolerance
• • 8. Smoker
• • 9. Pregnancy and lactating
• • 10. Taking alcohol
• • 11. Taking alcohol
• • 12. Haemoglobin levels for females ≤ 11.5 gm/dl and males ≤ 12.5 gm/dl
• • 13. Serum ferritin \< 15 µg/l at commencement of study