Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

Launched by NATIONAL CANCER INSTITUTE (NCI) · Jul 31, 2013

Keywords

ClinConnect Summary

This clinical trial is focused on collecting tissue samples from patients with certain types of cancer, including colorectal, gastric, bile duct, and pancreas cancers. Researchers need these samples to study new ways to treat tumors and improve cancer therapies. If you are an adult aged 18 or older, or a child aged 2 to 17 who is scheduled for a biopsy or surgery at the NIH Clinical Center, you may qualify to participate in this study.

Participants will have a small blood sample taken before their procedure, and some may undergo a process called leukapheresis, which involves removing white blood cells from their blood for study. During the surgery or biopsy, pieces of the tumor and some nearby normal tissue will also be collected for research. After the procedure, participants will have a routine follow-up appointment about six weeks later. This study aims to enhance our understanding of solid tumors and potentially lead to better treatments for cancer in the future.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Participants must be 2 years of age or older. Note: Participants greater than or equal to 2 and \< 18 years of age may only participate in research sample collection if the tissue acquisition is performed during a clinically indicated surgical procedure, and the biospecimen sampling (e.g., blood, urine, ascites, bile, or \[clinically indicated\] resected tumor tissue) does not add risk to the clinically indicated procedures.
• • Participants who have premalignant, primary or metastatic solid tumors based upon either radiographic or clinical suspicion, biochemical testing, a genetic predisposition, or histological/cytological analysis that requires surgery or biopsy as part of the diagnosis, prevention, treatment and/or follow up
• • Participants without solid tumors in whom a diagnostic, preventative, or therapeutic intervention is being performed, but for whom surgical quality and safety outcomes data are generated.
• • Participants should have laboratory and physical examination parameters within acceptable limits prior to biopsy or surgery.
• • Participants must be planning to undergo surgery or biopsy as part of their normal treatment plan.
• • Ability of participant to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• • None