C Reactive Protein (CRP) Intervention to Reduce Inappropriate Antibiotic Prescriptions in the Primary Healthcare Setting

Launched by OXFORD UNIVERSITY CLINICAL RESEARCH UNIT, VIETNAM · Aug 6, 2013

Keywords

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Eligibility criteria

• Inclusion Criteria:
• • Patients, aged 6 to 65 years, that visit one of the 10 selected primary healthcare centers
• • Suspected to have acute respiratory tract infection (ARI) by treating physician
• • Informed consent
• Exclusion Criteria:
• • Severe respiratory disease as determined by treating doctor
• • Any disease or symptom requiring hospital referral as determined by treating doctor
• • Immunosuppressed patients (e.g. HIV, long term steroid use)
• • Suspicion of tuberculosis
• • Evidence of acute or chronic liver disease (e.g. hepatitis or cirrhosis due to any cause)
• • Past medical history of: neoplastic disease, congestive cardiac failure, chronic obstructive pulmonary disease, insulin-dependent diabetes or renal disease
• • Pregnancy
• • No access to telephone
• • Not able to come for follow up visit on day 3 or 4.
• • Already taking antibiotics at the time of presentation
• • Symptoms present for more than 2 weeks
• • Presence of any sign of severe diseases as defined by the British Thoracic Society modified CRP-65 system for severity scoring of pneumonia in primary care.
• • For children (Age ≥ 6 years and \< 16 years) additional exclusion criteria include: Tachypnea, signs of chest wall in drawing, reduced consciousness, confusion, dehydration, hypothermia, severe malnutrition, unable to feed or drink, vomiting, and convulsions.