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Search / Trial NCT01931332

Intrathecal Diamorphine Versus Femoral Nerve Block in Primary Total Knee Arthroplasty

Launched by ROYAL DEVON AND EXETER NHS FOUNDATION TRUST · Aug 26, 2013

Trial Information

Current as of July 23, 2025

Completed

Keywords

Arthroplasty Analgesia

ClinConnect Summary

In 2008, the Prospect Working Group, a multidisciplinary expert panel, published their consensus guidelines on the relative merits of different anaesthetic and analgesic techniques for TKA based on a review of the available published literature up to 2005. These guidelines supported the use of general anaesthesia combined with a femoral nerve block for surgery and postoperative analgesia, or alternatively spinal anaesthesia with local anaesthetic combined with spinal morphine. The preference for femoral nerve block in favour of intrathecal opiates was as a consequence of the greater potenti...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adult patients scheduled for primary unilateral Total Knee Arthroplasty
  • Exclusion Criteria:
  • Uni-compartmental surgery, bilateral surgery, contra-indication to spinal anaesthesia or peripheral nerve block (anticoagulation, hydrocephalus, raised intracranial pressure), allergy to local anaesthetics or diamorphine, malignant hyperthermia or other concerns over general anaesthesia, chronic opiate use and chronic pain medication use (e.g. gabapentin, pregabalin, amitriptyline).

About Royal Devon And Exeter Nhs Foundation Trust

The Royal Devon and Exeter NHS Foundation Trust is a leading healthcare organization dedicated to delivering high-quality patient care and advancing medical research. Located in Exeter, the Trust is committed to innovation and excellence in clinical trials, facilitating studies that aim to improve health outcomes and enhance treatment options across various medical disciplines. With a strong emphasis on collaboration, the Trust partners with researchers, healthcare professionals, and patients to foster a research environment that prioritizes safety, ethical standards, and scientific integrity. Through its robust infrastructure and expertise, the Royal Devon and Exeter NHS Foundation Trust plays a vital role in the advancement of evidence-based medicine and the translation of research findings into clinical practice.

Locations

Exeter, Devon, United Kingdom

Patients applied

0 patients applied

Trial Officials

Matthew Grayling, MBBS

Principal Investigator

Royal Devon and Exeter Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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