Intrathecal Diamorphine Versus Femoral Nerve Block in Primary Total Knee Arthroplasty
Launched by ROYAL DEVON AND EXETER NHS FOUNDATION TRUST · Aug 26, 2013
Trial Information
Current as of July 24, 2025
Completed
Keywords
ClinConnect Summary
In 2008, the Prospect Working Group, a multidisciplinary expert panel, published their consensus guidelines on the relative merits of different anaesthetic and analgesic techniques for TKA based on a review of the available published literature up to 2005. These guidelines supported the use of general anaesthesia combined with a femoral nerve block for surgery and postoperative analgesia, or alternatively spinal anaesthesia with local anaesthetic combined with spinal morphine. The preference for femoral nerve block in favour of intrathecal opiates was as a consequence of the greater potenti...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult patients scheduled for primary unilateral Total Knee Arthroplasty
- Exclusion Criteria:
- • Uni-compartmental surgery, bilateral surgery, contra-indication to spinal anaesthesia or peripheral nerve block (anticoagulation, hydrocephalus, raised intracranial pressure), allergy to local anaesthetics or diamorphine, malignant hyperthermia or other concerns over general anaesthesia, chronic opiate use and chronic pain medication use (e.g. gabapentin, pregabalin, amitriptyline).
About Royal Devon And Exeter Nhs Foundation Trust
The Royal Devon and Exeter NHS Foundation Trust is a leading healthcare organization dedicated to delivering high-quality patient care and advancing medical research. Located in Exeter, the Trust is committed to innovation and excellence in clinical trials, facilitating studies that aim to improve health outcomes and enhance treatment options across various medical disciplines. With a strong emphasis on collaboration, the Trust partners with researchers, healthcare professionals, and patients to foster a research environment that prioritizes safety, ethical standards, and scientific integrity. Through its robust infrastructure and expertise, the Royal Devon and Exeter NHS Foundation Trust plays a vital role in the advancement of evidence-based medicine and the translation of research findings into clinical practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Exeter, Devon, United Kingdom
Patients applied
Trial Officials
Matthew Grayling, MBBS
Principal Investigator
Royal Devon and Exeter Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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