The Oslo Study of Clonidine in Elderly Patients With Delirium

Launched by OSLO UNIVERSITY HOSPITAL · Oct 7, 2013

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient \> 65 years old admitted to the Medical department
• • Delirium or subsyndromal delirium diagnosed within the last 48 hours
• • Signed informed consent from patient or relatives
• • Expected cooperation of the patients for the treatment and follow up
• Exclusion Criteria:
• • Symptomatic bradycardia, bradycardia due to sick-sinus-syndrome, second- or third- degree AV-block (not treated With pacemaker) or any other reason causing HR \<50 bpm at time of inclusion
• • Symptomatic hypotension or orthostatic hypotension, or a systolic BP \<120 at the time of inclusion
• • Ischemic stroke within the last 3 months or critical peripheral ischemia
• • Acute coronary syndrome, unstable or severe coronary heart disease (symptoms at minimal physical activity; NYHA 3 and 4) and moderate to severe heart failure (NYHA 3 and 4).
• • A diagnosis of polyneuropathy or pheochromocytoma
• • Renal insufficiency (estimated GFR\<30 ml/min according to the MDRD formula).
• • Body weight \< 45 kg.
• • Considered as moribund on admission.
• • Not able to take oral medications
• • Current use of tricyclic antidepressants, monoamine reuptake inhibitors or ciclosporin
• • Previously included in this study
• • Adverse reactions to clonidine or excipients (lactose, saccharose)
• • Not speaking or reading Norwegian
• • Any other condition as evaluated by the treating physician
• • Admitted to the ICU