Comparison of Redo PVI With vs. Without Renal Denervation for Recurrent AF After Initial PVI

Launched by MESHALKIN RESEARCH INSTITUTE OF PATHOLOGY OF CIRCULATION · Oct 8, 2013

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Eligibility criteria

• Inclusion Criteria:
• • Prior PVI ablation procedure for paroxysmal AF within past 2 years
• • Recurrent symptomatic paroxysmal AF despite prior PVI
• • History of essential hypertension requiring at least 2 chronic antihypertensive medications
• Exclusion Criteria:
• • Persistent AF after prior ablation
• • Congestive heart failure (NYHA III-IV functional class)
• • Left ventricle ejection fraction \< 35%
• • Left atrial diameter \>55 mm
• • An estimated glomerular filtration rate (eGFR) \< 45mL/min/1.73m2, using the MDRD calculation
• * Renal arteries unsuitable for RDN:
• • 1. Inability to access renal vasculature
• • 2. Main renal arteries \< 4 mm in diameter or \< 20 mm in length.
• • 3. Hemodynamically or anatomically significant renal artery abnormality or stenosis in either renal artery
• • 4. A history of prior renal artery intervention including balloon angioplasty or stenting that precludes a possibility of ablation treatment
• • 5. Multiple main renal arteries to either kidney
• • Unwillingness to participate