Pediatric Vasculitis Initiative

Launched by UNIVERSITY OF BRITISH COLUMBIA · Dec 4, 2013

Keywords

ClinConnect Summary

The Pediatric Vasculitis Initiative is a research study focused on understanding rare and serious blood vessel diseases in children, such as Granulomatosis With Polyangiitis and Takayasu Arteritis. These conditions can cause inflammation in important organs like the kidneys and lungs, and while some children may experience milder symptoms that can be treated with safer medications, others may need stronger treatments that could have serious side effects. The goal of this trial is to collect information from children diagnosed with these diseases to better classify their conditions, understand the best treatment options, and identify any potential risks associated with those treatments.

To participate, children must have been diagnosed with one of the targeted types of vasculitis before the age of 18. Healthy children and adults can also join as control participants, but certain health conditions may exclude them. Participants will contribute data through an online registry, which will help researchers gather enough information to improve how these diseases are diagnosed and treated in children. Additionally, samples like blood and tissue will be collected for laboratory studies to help find better ways to identify and manage these conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion criteria for vasculitis subjects:
• • Diagnosed with ANCA-associated vasculitis (AAV: such as Granulomatosis with Polyangiitis (GPA), Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Microscopic Polyangiitis (MPA)), Primary Angiitis of the Central Nervous System (PACNS), Unclassified vasculitis, Takayasu's Arteritis (TA) or Polyarteritis Nodosa (PAN) before age 18
• Inclusion criteria for healthy controls:
• • Healthy adult or child
• Exclusion Criteria for vasculitis subjects:
• • Diagnosed with other vasculitis subtypes not listed above
• • More than 20 years of age
• Exclusion criteria for healthy controls:
• • Donated greater than 20 ml of blood in the previous three weeks
• • Has an immune disorder or blood borne infectious diseases (such as HIV or Hepatitis)
• • Has vasculitis, multiple sclerosis, diabetes, an autoimmune disease, a thyroid condition, or other chronic conditions involving the heart, lungs, gut or kidney
• • Has a previous history of anaemia or abnormal blood clotting
• • Has a current or previous drug abuse problem