Evaluation of GCF MMP-1, -8 and Growth Factor Levels in Smokers With Periodontal Health
Launched by EGE UNIVERSITY · Dec 12, 2013
Trial Information
Current as of June 01, 2025
Completed
Keywords
ClinConnect Summary
The main objective of the present study was to investigate the GCF levels of MMP-1, MMP-8, TGF-β1, PDGF-AB and VEGF in smoker versus non-smoker periodontally healthy young adults.
A total of 32 periodontally healthy young adults including 16 smokers and 16 non-smokers, were recruited for the present cross-sectional study ( 18 female and 14 males; age range: 19 to 27 years).
All participants had a thorough full-mouth clinical examination. The measurement of probing depth (PD) and clinical attachment level (CAL) were assessed at six sites per tooth in the whole mouth, excluding third molars...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Periodontally and systemically healthy individuals
- • Have at least 20 teeth
- • \>10 cigarettes/day consumption for smoker group
- • Non-smokers subjects were selected from periodontally healthy participants who had never smoked.
- Exclusion Criteria:
- • Any health condition affecting their systemic status such as diabetes mellitus, immunologic disorders, human immunodeficiency virus infections, hepatitis were excluded
- • Also pregnant and lactating women and those taking oral contraceptive drugs were not included in the study.
- • Any antibiotic intake within the last 3 months and any periodontal treatment within 6 months
About Ege University
Ege University, a prestigious institution located in Izmir, Turkey, is renowned for its commitment to advancing medical research and education. As a prominent clinical trial sponsor, Ege University leverages its extensive academic resources and expertise in various healthcare fields to facilitate innovative clinical studies. The university is dedicated to enhancing patient care through rigorous research methodologies and collaboration with multidisciplinary teams, ensuring the development of effective therapies and interventions. With a strong focus on ethical standards and regulatory compliance, Ege University aims to contribute significantly to the global medical community by fostering groundbreaking discoveries and improving health outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
İzmir, , Turkey
Patients applied
Trial Officials
Gul Atilla, Professor
Study Director
Ege University School of Dentistry
Hatice Oya Turkoglu, Assoc. Professor
Study Chair
Ege University School of Dentistry
Harika Atmaca, PhD
Study Chair
Celal Bayar University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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