Effective Fluoride Concentration In Toothpaste For Dental Caries Prevention
Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Dec 14, 2013
Trial Information
Current as of August 15, 2025
Unknown status
Keywords
ClinConnect Summary
In developed countries, well-controlled clinical trials have investigated the effective fluoride level in toothpaste and provided irresistible data in relation to the caries controlling efficacy of tooth pastes. But there has been no such data reported in our part of the world. This indicates the need to determine the effective concentration of fluoride in locally manufactured tooth pastes for accomplishment of the goal of prevention against dental caries.
This will be a Parallel Group, Double-Blind, Randomized Controlled Trial, over a period of 18 months. The study will be conducted in a ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Regular school children of 12-15 years
- • 2. Presence of at least four molars
- Exclusion Criteria:
- • 1. Non- consenting cases
- • 2. Medically/physically compromised children
- • 3. Children under any kind of parallel fluoride regime (systemic or topical)
- • 4. Children consuming diet that is different from routine dietary practices
- • 5. Children using toothpaste with greater than 1100 ppm and less than 500 ppm of fluoride
- • 6. Children found with rampant caries
- • 7. Children found with all filled molars
- • 8. Children with any oral infection abscess, periodontitis etc
- • 9. Dentition with malocclusion
- • 10. Children undergoing orthodontic/prosthodontic treatment
- • 11. Children with Temporo mandibular joint disorder
- • 12. Children who missed the baseline examinations
- • 13. Loss to any follow-up cases
About Dow University Of Health Sciences
Dow University of Health Sciences (DUHS) is a premier educational and research institution based in Karachi, Pakistan, dedicated to advancing healthcare through innovative research and clinical excellence. As a clinical trial sponsor, DUHS integrates cutting-edge scientific inquiry with practical applications, fostering a collaborative environment that promotes the development of new treatments and therapies. The institution is committed to upholding the highest ethical standards in research, ensuring participant safety, and contributing to the global body of medical knowledge. With a focus on interdisciplinary collaboration and community health impact, DUHS plays a pivotal role in enhancing the quality of healthcare both locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Karachi, Sindh, Pakistan
Patients applied
Trial Officials
Dr. Ambrina Qureshi, BDS, M-Phil
Study Director
Head of Community Department, Dow University of Health Sciences, Karachi, Pakistan
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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