Desflurane-induced Myocardial Protection
Launched by NOBUYUKI KATORI · Dec 18, 2013
Trial Information
Current as of July 21, 2025
Unknown status
Keywords
ClinConnect Summary
Patients scheduled for aortic valve replacement with use of cardiopulmonary bypass are included in the study. Patients are assigned to desflurane group (Des) or propofol group (Prop). Des receives desflurane (1-2 MAC) inhalation between the induction of anesthesia and cardiopulmonary bypass (CPB). After the induction of CPB, the anesthesia in Des is switched to a total intravenous anesthesia (TIVA) with propofol. Prop receives a TIVA during the surgery. All patients receive a continuous infusion of remifentanil. Biomarker of myocardial damage troponin I is examined at 4 points; T1: after th...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients scheduled for aortic valve replacement with use of cardiopulmonary bypass.
- Exclusion Criteria:
- • Patients younger than 20 years old.
- • Recent myocardial infarction (within 1 year).
- • Renal dysfunction (GFR less than 50ml/min).
- • Known allergy to study drugs including propofol.
About Nobuyuki Katori
Nobuyuki Katori is a dedicated clinical trial sponsor committed to advancing medical research and innovation. With a strong focus on enhancing patient outcomes, Katori leads initiatives that prioritize ethical standards, rigorous scientific methodology, and collaboration with healthcare professionals. By fostering partnerships with academic institutions and industry leaders, Katori aims to drive the development of groundbreaking therapies across various therapeutic areas. Their commitment to transparency and compliance ensures that all clinical trials are conducted with the utmost integrity, contributing valuable insights to the medical community and improving healthcare practices globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tokyo, , Japan
Patients applied
Trial Officials
Makoto Suematsu, M.D., Ph.D
Study Chair
Keio University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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