Therapeutic Effect of Sodium Selenite on Oxidative Stress in Patients With Severe Sepsis
Launched by PAVOL JOZEF SAFARIK UNIVERSITY · Dec 31, 2013
Trial Information
Current as of July 04, 2025
Completed
Keywords
ClinConnect Summary
Patients will be divided into two groups. Se-group who received selenium supplementation during hospitalization in the form of sodium selenite pentahydrate at 750 mg/day for 6 days immediately after admission to our department (1000 mg of sodium selenite pentahydrate = 333 micrograms of selenium) (Selenase, Vivax; selenium hereinafter).
The placebo group will receive continuous saline NaCl 50 ml/day for 6 days as a continuous infusion (excluding additional infusion therapy). Patients will be further divided into subgroups according to OI on the day of admission to ICU. The oxygenation inde...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • sepsis, severe sepsis or septic shock, APACHE II score between 19 and 24 points after admission
- Exclusion Criteria:
- • mechanical ventilation for less than 24h, neuromuscular disease and terminal illness were also excluding criteria
About Pavol Jozef Safarik University
Pavol Jozef Safarik University is a distinguished institution dedicated to advancing health sciences and medical research. With a strong emphasis on innovation and interdisciplinary collaboration, the university actively engages in clinical trials that seek to enhance patient care and improve therapeutic outcomes. Its commitment to rigorous scientific methodology and ethical standards positions it as a leader in the academic research community, fostering advancements that translate into meaningful benefits for public health. Through its clinical trial initiatives, Pavol Jozef Safarik University aims to contribute to the global body of knowledge and support the development of new treatment modalities.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Košice, , Slovakia
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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